Pre_GI: OUP Neighbours

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Query: NC_008149:1221637 Yersinia pestis Nepal516, complete genome

D: 30.5812

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

Number of Neighbours: 63

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandSubject Host Description Compositional Similarity Proposed Island FlowSubject Island D
NC_010498:1210145Escherichia coli SMS-3-5, complete genome75.4596 %Subject ←→ Query26.7023
NC_010465:429095Yersinia pseudotuberculosis YPIII, complete genome76.97 %Subject ←→ Query29.1646
NC_008149:3648139Yersinia pestis Nepal516, complete genome76.9945 %Subject ←→ Query29.4565
NC_010465:804249Yersinia pseudotuberculosis YPIII, complete genome75.1348 %Subject ←→ Query29.499
NC_005810:4469156Yersinia pestis biovar Microtus str. 91001, complete genome78.462 %Subject ←→ Query29.5112
NC_008150:3711953Yersinia pestis Antiqua, complete genome76.97 %Subject ←→ Query29.7483
NC_008150:2599661Yersinia pestis Antiqua, complete genome75.2267 %Subject ←→ Query29.7787
NC_008149:4053363Yersinia pestis Nepal516, complete genome78.5815 %Subject ←→ Query30.0006
NC_004088:266543Yersinia pestis KIM, complete genome78.7377 %Subject ←→ Query30.0081
NC_006155:4302826Yersinia pseudotuberculosis IP 32953, complete genome75.0429 %Subject ←→ Query30.1556
NC_003143:2778494Yersinia pestis CO92, complete genome76.2316 %Subject ←→ Query30.2293
NC_012880:1711062*Dickeya dadantii Ech703, complete genome75.0582 %Subject ←→ Query30.2924
NC_008253:2198583Escherichia coli 536, complete genome77.2304 %Subject ←→ Query30.9551
NC_012880:1127997*Dickeya dadantii Ech703, complete genome75.1716 %Subject ←→ Query30.9614
NC_012912:2800884*Dickeya zeae Ech1591, complete genome76.8413 %Subject ←→ Query31.095
NC_006155:3040769Yersinia pseudotuberculosis IP 32953, complete genome76.8873 %Subject ←→ Query31.1041
NC_010634:2960000Yersinia pseudotuberculosis PB1/+, complete genome76.155 %Subject ←→ Query31.2014
NC_008150:3529430Yersinia pestis Antiqua, complete genome75.4228 %Subject ←→ Query31.4433
NC_015663:4447984Enterobacter aerogenes KCTC 2190 chromosome, complete genome76.7739 %Subject ←→ Query31.6444
NC_004088:1801819Yersinia pestis KIM, complete genome75.3738 %Subject ←→ Query31.8002
NC_014500:3519722Dickeya dadantii 3937 chromosome, complete genome75.1685 %Subject ←→ Query32.164
NC_008149:2411161Yersinia pestis Nepal516, complete genome76.2408 %Subject ←→ Query32.2349
NC_012912:1229333Dickeya zeae Ech1591, complete genome76.1642 %Subject ←→ Query32.2592
NC_007712:1893066*Sodalis glossinidius str. 'morsitans', complete genome76.8045 %Subject ←→ Query32.276
NC_012912:325913Dickeya zeae Ech1591, complete genome76.8566 %Subject ←→ Query32.3565
NC_013421:1954915*Pectobacterium wasabiae WPP163, complete genome78.6305 %Subject ←→ Query32.6483
NC_010465:1724000Yersinia pseudotuberculosis YPIII, complete genome75.9436 %Subject ←→ Query32.6727
NC_013592:3397304Dickeya dadantii Ech586, complete genome78.0116 %Subject ←→ Query32.6808
NC_010634:1565788Yersinia pseudotuberculosis PB1/+, complete genome82.0711 %Subject ←→ Query33.0113
NC_006155:1567306Yersinia pseudotuberculosis IP 32953, complete genome82.1691 %Subject ←→ Query33.2342
NC_012880:3645304Dickeya dadantii Ech703, complete genome77.4112 %Subject ←→ Query33.3293
NC_004088:3955933Yersinia pestis KIM, complete genome75.7322 %Subject ←→ Query33.4603
NC_013421:3752619*Pectobacterium wasabiae WPP163, complete genome75.1716 %Subject ←→ Query33.6393
NC_003143:2849377Yersinia pestis CO92, complete genome75.4596 %Subject ←→ Query33.8521
NC_010159:1861465Yersinia pestis Angola, complete genome75.72 %Subject ←→ Query33.8947
NC_007712:4023516Sodalis glossinidius str. 'morsitans', complete genome76.4553 %Subject ←→ Query33.8969
NC_005810:2613456Yersinia pestis biovar Microtus str. 91001, complete genome75.3462 %Subject ←→ Query33.9433
NC_010159:1101241Yersinia pestis Angola, complete genome76.2132 %Subject ←→ Query33.9894
NC_005810:3238391Yersinia pestis biovar Microtus str. 91001, complete genome76.6636 %Subject ←→ Query34.2139
NC_003143:645559Yersinia pestis CO92, complete genome76.587 %Subject ←→ Query34.4007
NC_004547:843475*Erwinia carotovora subsp. atroseptica SCRI1043, complete genome75.3891 %Subject ←→ Query34.6881
NC_012779:3316877Edwardsiella ictaluri 93-146, complete genome76.1305 %Subject ←→ Query34.9445
NC_009792:808332Citrobacter koseri ATCC BAA-895, complete genome78.1924 %Subject ←→ Query35.0274
NC_010694:3055403Erwinia tasmaniensis, complete genome75.3309 %Subject ←→ Query35.0644
NC_010067:3753971Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, complete75.3125 %Subject ←→ Query35.7065
NC_013421:1038500Pectobacterium wasabiae WPP163, complete genome75.6066 %Subject ←→ Query35.7825
NC_013421:1545386Pectobacterium wasabiae WPP163, complete genome77.6685 %Subject ←→ Query35.9253
NC_012779:2424967*Edwardsiella ictaluri 93-146, complete genome76.0355 %Subject ←→ Query35.992
NC_013961:3083816Erwinia amylovora, complete genome76.1366 %Subject ←→ Query36.2172
NC_013421:1143500Pectobacterium wasabiae WPP163, complete genome75.9161 %Subject ←→ Query36.4256
NC_007712:2287053Sodalis glossinidius str. 'morsitans', complete genome75.8915 %Subject ←→ Query36.533
NC_012779:2064582Edwardsiella ictaluri 93-146, complete genome75.4044 %Subject ←→ Query37.0151
NC_007712:433500Sodalis glossinidius str. 'morsitans', complete genome76.6176 %Subject ←→ Query37.0845
NC_011149:2040396Salmonella enterica subsp. enterica serovar Agona str. SL483,77.6961 %Subject ←→ Query37.9381
NC_012880:1585255Dickeya dadantii Ech703, complete genome75.193 %Subject ←→ Query39.2242
NC_013508:1687432Edwardsiella tarda EIB202, complete genome75.1532 %Subject ←→ Query39.3906
NC_012779:3176820*Edwardsiella ictaluri 93-146, complete genome75.1532 %Subject ←→ Query39.7546
NC_012779:2856051Edwardsiella ictaluri 93-146, complete genome77.7574 %Subject Query40.677
NC_014228:3282500Xenorhabdus nematophila ATCC 19061, complete genome75.864 %Subject Query41.4806
NC_012779:1449500*Edwardsiella ictaluri 93-146, complete genome77.886 %Subject Query41.6091
NC_013508:2356865*Edwardsiella tarda EIB202, complete genome75.3002 %Subject Query44.5077
NC_012779:2957000Edwardsiella ictaluri 93-146, complete genome75.1961 %Subject Query46.4521
NC_009778:1141716Enterobacter sakazakii ATCC BAA-894, complete genome75.0643 %Subject Query48.5924