Pre_GI: OUP Neighbours

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Query: NC_007385:157516 Shigella sonnei Ss046 plasmid pSS_046, complete sequence

D: 38.0958

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

Number of Neighbours: 29




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandSubject Host Description Compositional Similarity Proposed Island FlowSubject Island D
NC_003277:22257Salmonella typhimurium LT2 plasmid pSLT, complete sequence77.8094 %Subject ←→ Query31.1132
NC_008563:3119284Escherichia coli APEC O1, complete genome79.4945 %Subject ←→ Query31.9127
NC_007384:1763375Shigella sonnei Ss046, complete genome75.0827 %Subject ←→ Query33.4012
NC_013956:4579759Pantoea ananatis LMG 20103 chromosome, complete genome77.9841 %Subject ←→ Query34.8158
NC_009832:1946401Serratia proteamaculans 568, complete genome79.8805 %Subject ←→ Query35.908
NC_004631:685357*Salmonella enterica subsp. enterica serovar Typhi Ty2, complete76.3572 %Subject ←→ Query36.1113
NC_007608:97092Shigella boydii Sb227 plasmid pSB4_227, complete sequence84.617 %Subject ←→ Query36.3239
NC_009801:3374501*Escherichia coli E24377A, complete genome80.7659 %Subject ←→ Query36.3653
NC_004431:1352906Escherichia coli CFT073, complete genome81.8903 %Subject ←→ Query36.4239
NC_002695:2158314Escherichia coli O157:H7 str. Sakai, complete genome81.4645 %Subject ←→ Query36.4725
AP010958:1472506Escherichia coli O103:H2 str. 12009 DNA, complete genome83.1342 %Subject ←→ Query36.7127
NC_011751:1377457Escherichia coli UMN026 chromosome, complete genome81.9822 %Subject ←→ Query36.813
NC_010660:33109Shigella boydii CDC 3083-94 plasmid pBS512_211, complete sequence75.7567 %Subject ←→ Query36.8677
NC_003198:2297837Salmonella enterica subsp. enterica serovar Typhi str. CT18,75.2635 %Subject ←→ Query37.159
NC_002695:2893951Escherichia coli O157:H7 str. Sakai, complete genome82.2212 %Subject ←→ Query37.275
NC_011080:2342672Salmonella enterica subsp. enterica serovar Newport str. SL254,75.0797 %Subject ←→ Query37.4165
NC_009648:3476000Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genome79.2034 %Subject ←→ Query37.4593
NC_006905:2355290Salmonella enterica subsp. enterica serovar Choleraesuis str75.3186 %Subject ←→ Query37.6094
NC_011750:1931384Escherichia coli IAI39 chromosome, complete genome81.5104 %Subject ←→ Query37.6581
NC_014500:894136Dickeya dadantii 3937 chromosome, complete genome75.7384 %Subject ←→ Query37.8586
NC_013716:4824541*Citrobacter rodentium ICC168, complete genome75.242 %Subject ←→ Query38.2235
NC_002655:1909139Escherichia coli O157:H7 EDL933, complete genome82.9013 %Subject ←→ Query38.4667
NC_011750:919953Escherichia coli IAI39 chromosome, complete genome81.057 %Subject ←→ Query38.6045
NC_011750:2009889Escherichia coli IAI39 chromosome, complete genome81.2684 %Subject ←→ Query39.0625
NC_012779:305969Edwardsiella ictaluri 93-146, complete genome77.981 %Subject ←→ Query39.836
NC_014121:1822895Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, complete79.5711 %Subject ←→ Query40.59
NC_014228:3282500Xenorhabdus nematophila ATCC 19061, complete genome76.9761 %Subject ←→ Query41.4806
NC_012779:2928000*Edwardsiella ictaluri 93-146, complete genome75.2298 %Subject ←→ Query41.5453
NC_010660:175200*Shigella boydii CDC 3083-94 plasmid pBS512_211, complete sequence85.2451 %Subject ←→ Query46.3542