Pre_GI: OUP Neighbours

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Query: NC_005956:1139342 Bartonella henselae str. Houston-1, complete genome

D: 23.553

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.

Number of Neighbours: 18

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandSubject Host Description Compositional Similarity Proposed Island FlowSubject Island D
NC_015759:536929*Weissella koreensis KACC 15510 chromosome, complete genome75.2359 %Subject ←→ Query21.6744
NC_007429:585774*Chlamydia trachomatis A/HAR-13, complete genome75.0613 %Subject ←→ Query24.5136
NC_008783:145305Bartonella bacilliformis KC583, complete genome75.6158 %Subject ←→ Query26.0032
NC_005955:1284500*Bartonella quintana str. Toulouse, complete genome75.1471 %Subject ←→ Query27.0975
NC_015744:900000*Chlamydia trachomatis L2c chromosome, complete genome75.0368 %Subject ←→ Query27.6386
NC_012846:2004711*Bartonella grahamii as4aup, complete genome76.299 %Subject ←→ Query27.95
NC_013721:1581370*Gardnerella vaginalis 409-05, complete genome75.9835 %Subject ←→ Query29.3242
NC_015276:2804874*Marinomonas mediterranea MMB-1 chromosome, complete genome79.4669 %Subject ←→ Query29.8547
NC_010161:1598000*Bartonella tribocorum CIP 105476, complete genome89.2555 %Subject ←→ Query30.262
NC_015276:2852010Marinomonas mediterranea MMB-1 chromosome, complete genome78.4743 %Subject ←→ Query30.4475
NC_010161:1949637Bartonella tribocorum CIP 105476, complete genome75.098 %Subject ←→ Query31.1808
NC_005956:1648000*Bartonella henselae str. Houston-1, complete genome76.8321 %Subject ←→ Query31.2454
NC_010161:2548254Bartonella tribocorum CIP 105476, complete genome76.1703 %Subject ←→ Query31.3939
NC_006138:1245944*Desulfotalea psychrophila LSv54, complete genome75.8854 %Subject ←→ Query32.3163
NC_010161:2155500*Bartonella tribocorum CIP 105476, complete genome75.6005 %Subject ←→ Query32.5841
NC_015276:2171355*Marinomonas mediterranea MMB-1 chromosome, complete genome77.9351 %Subject ←→ Query32.7927
NC_015581:128350*Thioalkalimicrobium cyclicum ALM1 chromosome, complete genome78.1403 %Subject Query34.2108
NC_002488:2502000*Xylella fastidiosa 9a5c, complete genome77.1109 %Subject Query35.6822