Pre_GI: OUP Neighbours

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Query: NC_003143:4006884 Yersinia pestis CO92, complete genome

D: 29.6176

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

Number of Neighbours: 95

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandSubject Host Description Compositional Similarity Proposed Island FlowSubject Island D
NC_009792:808332Citrobacter koseri ATCC BAA-895, complete genome77.6777 %Subject ←→ Query35.0274
NC_013716:4824541*Citrobacter rodentium ICC168, complete genome77.1262 %Subject ←→ Query38.2235
NC_013283:113660Cronobacter turicensis plasmid pCTU1, complete sequence75.5729 %Subject Query42.151
NC_014500:894136Dickeya dadantii 3937 chromosome, complete genome75.6311 %Subject ←→ Query37.8586
NC_014500:2616423Dickeya dadantii 3937 chromosome, complete genome76.1826 %Subject ←→ Query29.9702
NC_013592:1424560Dickeya dadantii Ech586, complete genome79.3045 %Subject Query41.2418
NC_013592:2160000Dickeya dadantii Ech586, complete genome77.1078 %Subject ←→ Query33.4874
NC_012912:325913Dickeya zeae Ech1591, complete genome75.2145 %Subject ←→ Query32.3565
NC_012912:2800884*Dickeya zeae Ech1591, complete genome75.5055 %Subject ←→ Query31.095
NC_012912:2285778Dickeya zeae Ech1591, complete genome76.7831 %Subject ←→ Query33.4887
NC_012912:1295653Dickeya zeae Ech1591, complete genome75.5362 %Subject ←→ Query31.554
NC_012912:647369Dickeya zeae Ech1591, complete genome78.5049 %Subject ←→ Query37.7391
NC_012779:1449500*Edwardsiella ictaluri 93-146, complete genome75.913 %Subject Query41.6091
NC_012779:3176820*Edwardsiella ictaluri 93-146, complete genome78.1373 %Subject Query39.7546
NC_012779:305969Edwardsiella ictaluri 93-146, complete genome75.5086 %Subject Query39.836
NC_012779:2928000*Edwardsiella ictaluri 93-146, complete genome76.4399 %Subject Query41.5453
NC_012779:2424967*Edwardsiella ictaluri 93-146, complete genome76.2255 %Subject ←→ Query35.992
NC_012779:996879Edwardsiella ictaluri 93-146, complete genome76.9638 %Subject Query39.7678
NC_012779:2281700*Edwardsiella ictaluri 93-146, complete genome77.932 %Subject Query40.1776
NC_012779:957558Edwardsiella ictaluri 93-146, complete genome76.2531 %Subject ←→ Query38.2879
NC_012779:2064582Edwardsiella ictaluri 93-146, complete genome76.9056 %Subject ←→ Query37.0151
NC_012779:3316877Edwardsiella ictaluri 93-146, complete genome80.0705 %Subject ←→ Query34.9445
NC_013508:876431*Edwardsiella tarda EIB202, complete genome77.7451 %Subject Query41.7282
NC_015663:1902344*Enterobacter aerogenes KCTC 2190 chromosome, complete genome78.5876 %Subject ←→ Query31.1284
NC_015968:4389871Enterobacter asburiae LF7a chromosome, complete genome75.242 %Subject ←→ Query30.7332
NC_015968:2195645Enterobacter asburiae LF7a chromosome, complete genome77.7849 %Subject ←→ Query33.0849
NC_014121:1822895Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, complete78.9614 %Subject Query40.59
NC_014121:1038554Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, complete77.2733 %Subject ←→ Query34.8127
NC_013961:3083816Erwinia amylovora, complete genome77.5705 %Subject ←→ Query36.2172
NC_010694:962383Erwinia tasmaniensis, complete genome78.1219 %Subject ←→ Query30.0928
NC_010694:3055403Erwinia tasmaniensis, complete genome78.2904 %Subject ←→ Query35.0644
NC_010694:2189652*Erwinia tasmaniensis, complete genome76.8689 %Subject ←→ Query37.4179
NC_008563:3119284Escherichia coli APEC O1, complete genome79.4485 %Subject ←→ Query31.9127
NC_004431:1352906Escherichia coli CFT073, complete genome77.1691 %Subject ←→ Query36.4239
NC_011750:919953Escherichia coli IAI39 chromosome, complete genome75.6556 %Subject ←→ Query38.6045
NC_011750:1931384Escherichia coli IAI39 chromosome, complete genome76.6299 %Subject ←→ Query37.6581
AP010958:1472506Escherichia coli O103:H2 str. 12009 DNA, complete genome75.674 %Subject ←→ Query36.7127
NC_002655:1909139Escherichia coli O157:H7 EDL933, complete genome75.8456 %Subject ←→ Query38.4667
NC_002695:2893951Escherichia coli O157:H7 str. Sakai, complete genome75.9926 %Subject ←→ Query37.275
NC_011751:1377457Escherichia coli UMN026 chromosome, complete genome77.4203 %Subject ←→ Query36.813
NC_009648:3720000*Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genome75.2665 %Subject ←→ Query36.7036
NC_009648:3476000Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genome78.3915 %Subject ←→ Query37.4593
NC_009648:2465613*Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genome77.6532 %Subject Query50.7802
NC_009648:1487692Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genome77.6256 %Subject Query49.6231
NC_013956:4579759Pantoea ananatis LMG 20103 chromosome, complete genome77.6011 %Subject ←→ Query34.8158
NC_014562:1883517*Pantoea vagans C9-1 chromosome, complete genome75.867 %Subject ←→ Query34.2182
NC_013421:2720500Pectobacterium wasabiae WPP163, complete genome76.5349 %Subject ←→ Query34.6251
NC_012962:3568046Photorhabdus asymbiotica, complete genome75.3125 %Subject ←→ Query37.813
NC_010067:3753971Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, complete76.7586 %Subject ←→ Query35.7065
NC_011149:3930358Salmonella enterica subsp. enterica serovar Agona str. SL483,76.5748 %Subject ←→ Query38.0507
NC_011149:2294500Salmonella enterica subsp. enterica serovar Agona str. SL483,76.8536 %Subject ←→ Query38.0253
NC_006905:3942753Salmonella enterica subsp. enterica serovar Choleraesuis str77.6134 %Subject ←→ Query35.749
NC_006905:2355290Salmonella enterica subsp. enterica serovar Choleraesuis str77.4234 %Subject ←→ Query37.6094
NC_011083:4020000Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,76.6023 %Subject ←→ Query37.6885
NC_011080:3976441Salmonella enterica subsp. enterica serovar Newport str. SL254,76.7218 %Subject ←→ Query36.5166
NC_011080:2342672Salmonella enterica subsp. enterica serovar Newport str. SL254,77.595 %Subject ←→ Query37.4165
NC_006511:682863*Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC76.1274 %Subject ←→ Query36.3874
NC_006511:3794017Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC76.1152 %Subject ←→ Query37.3602
NC_010102:3955479Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,76.5227 %Subject ←→ Query37.2943
NC_003198:3824187Salmonella enterica subsp. enterica serovar Typhi str. CT18,78.0515 %Subject ←→ Query35.4207
NC_003198:2297837Salmonella enterica subsp. enterica serovar Typhi str. CT18,77.6624 %Subject ←→ Query37.159
NC_004631:3809678Salmonella enterica subsp. enterica serovar Typhi Ty2, complete77.8493 %Subject ←→ Query36.1376
NC_004631:685357*Salmonella enterica subsp. enterica serovar Typhi Ty2, complete76.8566 %Subject ←→ Query36.1113
NC_003197:4005857Salmonella typhimurium LT2, complete genome76.6299 %Subject ←→ Query36.3904
NC_009832:358291Serratia proteamaculans 568, complete genome75.9069 %Subject ←→ Query31.5844
NC_009832:1946401Serratia proteamaculans 568, complete genome78.7255 %Subject ←→ Query35.908
NC_015566:316340Serratia sp. AS12 chromosome, complete genome76.829 %Subject ←→ Query34.9699
NC_015566:4662171Serratia sp. AS12 chromosome, complete genome79.4087 %Subject Query41.8855
NC_015567:313035Serratia sp. AS9 chromosome, complete genome76.6759 %Subject ←→ Query32.0282
NC_007712:2287053Sodalis glossinidius str. 'morsitans', complete genome76.6146 %Subject ←→ Query36.533
NC_007712:1893066*Sodalis glossinidius str. 'morsitans', complete genome75.8793 %Subject ←→ Query32.276
NC_007712:433500Sodalis glossinidius str. 'morsitans', complete genome75.1654 %Subject ←→ Query37.0845
NC_007712:4023516Sodalis glossinidius str. 'morsitans', complete genome75.1134 %Subject ←→ Query33.8969
NC_014228:3282500Xenorhabdus nematophila ATCC 19061, complete genome81.011 %Subject Query41.4806
NC_014228:3022903Xenorhabdus nematophila ATCC 19061, complete genome76.3664 %Subject ←→ Query39.1304
NC_014228:2883500Xenorhabdus nematophila ATCC 19061, complete genome77.8615 %Subject ←→ Query39.0811
NC_010159:1101241Yersinia pestis Angola, complete genome77.1078 %Subject ←→ Query33.9894
NC_008150:3529430Yersinia pestis Antiqua, complete genome77.8186 %Subject ←→ Query31.4433
NC_008150:1420825*Yersinia pestis Antiqua, complete genome78.1434 %Subject ←→ Query37.0184
NC_005810:4469156Yersinia pestis biovar Microtus str. 91001, complete genome83.5294 %Subject ←→ Query29.5112
NC_005810:3238391Yersinia pestis biovar Microtus str. 91001, complete genome77.4663 %Subject ←→ Query34.2139
NC_005810:1794490*Yersinia pestis biovar Microtus str. 91001, complete genome78.2721 %Subject ←→ Query37.035
NC_003143:645559Yersinia pestis CO92, complete genome77.5429 %Subject ←→ Query34.4007
NC_003143:2778494Yersinia pestis CO92, complete genome75.6373 %Subject ←→ Query30.2293
NC_003143:2137945*Yersinia pestis CO92, complete genome77.3897 %Subject ←→ Query37.3318
NC_004088:3955933Yersinia pestis KIM, complete genome77.5031 %Subject ←→ Query33.4603
NC_004088:266543Yersinia pestis KIM, complete genome83.7255 %Subject ←→ Query30.0081
NC_008149:4053363Yersinia pestis Nepal516, complete genome83.7837 %Subject ←→ Query30.0006
NC_006155:4105542Yersinia pseudotuberculosis IP 32953, complete genome76.7279 %Subject ←→ Query34.268
NC_006155:1567306Yersinia pseudotuberculosis IP 32953, complete genome76.5135 %Subject ←→ Query33.2342
NC_006155:4302826Yersinia pseudotuberculosis IP 32953, complete genome94.0319 %Subject ←→ Query30.1556
NC_010634:4045794Yersinia pseudotuberculosis PB1/+, complete genome76.6881 %Subject ←→ Query34.0011
NC_010634:1565788Yersinia pseudotuberculosis PB1/+, complete genome75.8333 %Subject ←→ Query33.0113
NC_010634:4234932Yersinia pseudotuberculosis PB1/+, complete genome91.0784 %Subject ←→ Query30.3016
NC_010465:429095Yersinia pseudotuberculosis YPIII, complete genome90.6587 %Subject ←→ Query29.1646