Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_017513: Neisseria meningitidis G2136 chromosome, complete genome

NCBI: NC_017513

Host Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria

General Information: The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
19081*3004420964Island text1.7802831.308828.7489Neighbours24BLASTN+9081.gbk
2115870*13809922230Island text2.4516338.151839.3435Neighbours35BLASTN115870.gbk
3141291*16838227092Island text1.3686333.742735.6864Neighbours320BLASTN+141291.gbk
444994947970629758Island text1.9505541.316144.0404Neighbours24BLASTN+449949.gbk
5548882*57272823847Island text1.5327133.205328.1936Neighbours35BLASTN+548882.gbk
6618500*64931230813Island text1.8446133.410520.0346Neighbours24BLASTN+618500.gbk
788734491239225049Island text2.3784134.972235.3154Neighbours24BLASTN+887344.gbk
8997716102009922384Island text2.1860437.432725.5431Neighbours35BLASTN+997716.gbk
91331623136081229190Island text1.5108932.131654.3915Neighbours24BLASTN+1331623.gbk
101845069*186359918531Island text2.7558840.270322.9107Neighbours24BLASTN+1845069.gbk
112017000203459917600Island text1.5110434.800645.6907Neighbours35BLASTN+2017000.gbk
122134308*216069926392Island text1.5506328.80934.7545Neighbours35BLASTN+2134308.gbk