Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_017512: Neisseria meningitidis WUE 2594, complete genome

NCBI: NC_017512

Host Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria

General Information: The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
152228*7687924652Island text2.7256339.217730.0215Neighbours24BLASTN52228.gbk
242508545751732433Island text1.7732336.452753.0726Neighbours24BLASTN425085.gbk
352689254578118890Island text1.4656130.161727.6404Neighbours24BLASTN+526892.gbk
4642229*66059918371Island text1.8507427.97324.9117Neighbours35BLASTN+642229.gbk
576000078231722318Island text1.4914129.480841.5733Neighbours24BLASTN760000.gbk
6789600*81259923000Island text1.4711828.599234.1576Neighbours24BLASTN789600.gbk
71264542*128459920058Island text2.2400336.062622.2317Neighbours24BLASTN1264542.gbk
81294970*131960424635Island text1.5841729.897925.5646Neighbours24BLASTN+1294970.gbk
91824966*184659921634Island text1.8579333.775322.1446Neighbours24BLASTN+1824966.gbk
102087098*211542228325Island text1.5007134.879641.2352Neighbours320BLASTN+2087098.gbk
112116295*214222125927Island text1.9315833.180928.2251Neighbours35BLASTN2116295.gbk
122161000*218601625017Island text1.6337933.575248.17Neighbours24BLASTN+2161000.gbk
132209000*223199923000Island text2.051341.4445.7407Neighbours35BLASTN2209000.gbk