Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_017316: Enterococcus faecalis OG1RF chromosome, complete genome

NCBI: NC_017316

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
1157254*17770720454Island text1.5970223.363335.2674BLASTN157254.gbk
2203233*22745324221Island text2.4680328.562243.7411Neighbours344BLASTN203233.gbk
31840462*186238121920Island text2.5262331.173442.9017Neighbours325BLASTN+1840462.gbk
42466244*248876222519Island text1.6235322.727440.6779Neighbours325BLASTN+2466244.gbk
52581781*260250520725Island text2.3407927.615445.0201Neighbours325BLASTN+2581781.gbk
62637707266384726141Island text1.6769924.858939.81Neighbours325BLASTN2637707.gbk
72710021*273226622246Island text1.5817723.754740.3724Neighbours325BLASTN2710021.gbk