Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_017066: Rickettsia typhi str. TH1527 chromosome, complete genome

NCBI: NC_017066

Host Lineage: Rickettsia typhi; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. This organism causes murine typhus and is an obligate intracellular pathogen that infects both the flea vector and hosts such as human, rat, and mouse. R. prowazekii, and genomic comparisons demonstrate colinearity and similarity to the genome of that organism except for two independent inversions near the origin and terminus. In the flea vector, the bacterium penetrates the gut epithelial barrier and is found in the feces which become infective.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
133268*5417820911Island text1.623916.887922.297Neighbours21BLASTN+33268.gbk
257571*8059923029Island text3.2235511.670122.7007Neighbours21BLASTN+57571.gbk
3140853*18445043598Island text1.8894314.358423.1884Neighbours21BLASTN+140853.gbk
4243913*26235118439Island text1.7178612.165617.7366Neighbours21BLASTN+243913.gbk
5262839*28204719209Island text1.5192412.448315.7632Neighbours21BLASTN+262839.gbk
6312000*33435322354Island text1.573813.636916.689Neighbours21BLASTN312000.gbk
7683000*70515222153Island text1.8614413.006620.8826Neighbours21BLASTN683000.gbk
8811565*83709925535Island text1.8805813.97225.8615Neighbours21BLASTN811565.gbk
9995629*102267127043Island text1.9022715.66425.8931Neighbours21BLASTN995629.gbk