Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_016768: Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

NCBI: NC_016768

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
147650049987823379Island text1.7739318.081729.0306Neighbours11BLASTN+476500.gbk
283000085266822669Island text1.7487817.480417.027Neighbours11BLASTN+830000.gbk
31279178130009920922Island text1.6036321.458532.037Neighbours11BLASTN+1279178.gbk
41769332*179265723326Island text1.5150122.264138.0375Neighbours11BLASTN+1769332.gbk
52101751212511823368Island text1.4898516.634229.2788Neighbours11BLASTN2101751.gbk
62521225254522524001Island text1.5297518.740434.776Neighbours11BLASTN+2521225.gbk
72704350273081726468Island text1.9850120.349319.4406Neighbours11BLASTN+2704350.gbk
82764000278670022701Island text1.4987816.579519.6553Neighbours11BLASTN+2764000.gbk
93296478*331837021893Island text2.2364822.977127.7005Neighbours11BLASTN+3296478.gbk
103774105379881924715Island text1.8008417.293928.0777Neighbours11BLASTN+3774105.gbk