Pre_GI Gene

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Host: NC_018939 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_018939:547793 Helicobacter pylori 26695 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
547793548035243cag pathogenicity island protein EpsilonQuickGO ontologyBLASTP
548035548151117cag island proteinQuickGO ontology
5481445495891446cag pathogenicity island protein cag3QuickGO ontologyBLASTP
549599550108510cag pathogenicity island protein cag4QuickGO ontologyBLASTP
5502275524732247cag pathogenicity island protein BetaQuickGO ontologyBLASTP
552482553474993cag pathogenicity island protein alphaQuickGO ontologyBLASTP
553479554078600cag pathogenicity island protein cag6QuickGO ontologyBLASTP
554059554226168hypothetical proteinBLASTP
5542165599995784cag pathogenicity island protein cag7QuickGO ontologyBLASTP
5600145615821569cag pathogenicity island protein cag8QuickGO ontologyBLASTP
5616355632421608cag pathogenicity island protein cag9QuickGO ontologyBLASTP
563247564005759cag pathogenicity island protein cag10QuickGO ontologyBLASTP
564391565047657cag pathogenicity island protein cag11QuickGO ontologyBLASTP
565083565754672cag pathogenicity island protein TQuickGO ontologyBLASTP
565788565925138cag pathogenicity island protein TQuickGO ontologyBLASTP
566136566726591cag pathogenicity island protein SQuickGO ontologyBLASTP
567240567551312cag pathogenicity island protein RQuickGO ontologyBLASTP
568248568427180hypothetical proteinBLASTP