Pre_GI Gene

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Host: NC_018939 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_018939:1583653 Helicobacter pylori 26695 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
15829941583656663glycerol-3-phosphate acyltransferase PlsYQuickGO ontologyBLASTP
15836531584006354hypothetical proteinBLASTP
15839901584316327hypothetical proteinBLASTP
158447015871032634iron-regulated outer membrane proteinQuickGO ontologyBLASTP
15871431587250108hypothetical protein
158733015884901161selenocysteine synthaseQuickGO ontologyBLASTP
158859215897791188transcription elongation factor NusAQuickGO ontologyBLASTP
15901321590671540hypothetical proteinBLASTP
159067215945113840type IIS restriction enzyme R and M protein ECO57IRQuickGO ontologyBLASTP
15945131594800288hypothetical proteinBLASTP
159721916001222904type III restriction enzyme R protein resQuickGO ontologyBLASTP
16001251600712588type III R-M system modification enzymeQuickGO ontologyBLASTP
160070916020611353type III DNA modification enzymeQuickGO ontologyBLASTP
160211116039821872ATP-dependent DNA helicase RecGQuickGO ontologyBLASTP
16040641604411348hypothetical proteinBLASTP
16044151605050636hypothetical proteinBLASTP
16050471605799753exodeoxyribonuclease IIIQuickGO ontologyBLASTP