Pre_GI Gene

Some Help

Host: NC_017381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017381:982216 Helicobacter pylori 2018 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
9822169833731158cell division proteinQuickGO ontologyBLASTP
983642983881240hypothetical proteinBLASTP
983905984462558hypothetical proteinBLASTP
984603984938336hypothetical proteinBLASTP
985286986110825Mechanosensitive channelQuickGO ontologyBLASTP
986252986437186hypothetical proteinBLASTP
9885339899601428DNA topoisomerase IQuickGO ontologyBLASTP
989960990463504DNA topoisomerase IQuickGO ontologyBLASTP
991578992324747Conjugal plasmid transfer system proteinQuickGO ontologyBLASTP
992318992845528Conjugal plasmid transfer system proteinQuickGO ontologyBLASTP
994162994458297hypothetical proteinBLASTP
994448994711264hypothetical proteinBLASTP
994708995007300hypothetical proteinBLASTP
995007995543537P-type DNA transfer ATPaseQuickGO ontologyBLASTP
995576995947372P-type DNA transfer ATPaseQuickGO ontologyBLASTP
995944996399456hypothetical proteinBLASTP
996396996686291hypothetical proteinBLASTP
996687997244558hypothetical proteinBLASTP
9972459989871743conjugal transfer proteinQuickGO ontologyBLASTP
999227999361135hypothetical proteinBLASTP
9995021000038537integraserecombinaseQuickGO ontologyBLASTP
10000051000592588integraserecombinaseQuickGO ontologyBLASTP
10006261000742117hypothetical protein
10042431004386144hypothetical proteinBLASTP
10045611004923363hypothetical proteinBLASTP
10050501005421372hypothetical proteinBLASTP
100539310068351443hypothetical proteinBLASTP
10068321006945114hypothetical protein