Pre_GI Gene

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Host: NC_017379 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017379:505350 Helicobacter pylori Puno135 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
505350505679330cag pathogenicity island protein EpsilonQuickGO ontologyBLASTP
5057005071451446cag pathogenicity island protein 3QuickGO ontologyBLASTP
507150507659510cag pathogenicity island protein 4QuickGO ontologyBLASTP
5077785100242247CAG pathogenicity island protein 5QuickGO ontologyBLASTP
510033511025993cag pathogenicity island protein cag alphaQuickGO ontologyBLASTP
511030511629600cag pathogenicity island proteinQuickGO ontologyBLASTP
511642511776135hypothetical proteinBLASTP
5117665173695604cag pathogenicity island proteinQuickGO ontologyBLASTP
5173845189491566cag pathogenicity island proteinQuickGO ontologyBLASTP
5190025206091608cag pathogenicity island protein WQuickGO ontologyBLASTP
520614521372759cag pathogenicity island proteinQuickGO ontologyBLASTP
521631522278648cag pathogenicity island proteinQuickGO ontologyBLASTP
522294523136843CAG pathogenicity island protein TQuickGO ontologyBLASTP
523338523937600CAG pathogenicity island protein SQuickGO ontologyBLASTP
524371524475105hypothetical proteinBLASTP
524641524820180hypothetical proteinBLASTP
524849525154306cag pathogenicity island proteinQuickGO ontologyBLASTP
525212525361150hypothetical proteinBLASTP
525653525796144hypothetical proteinBLASTP
526441526653213hypothetical proteinBLASTP
5268855280151131cag pathogenicity island protein MQuickGO ontologyBLASTP