Pre_GI Gene

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Host: NC_017379 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017379:1035464 Helicobacter pylori Puno135 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
103546410375242061topoisomerase IQuickGO ontologyBLASTP
10375281037776249hypothetical proteinBLASTP
10377761037919144hypothetical protein
10381641038820657PARA proteinQuickGO ontologyBLASTP
10389031039187285hypothetical proteinBLASTP
10426101042924315hypothetical proteinBLASTP
10429171043198282hypothetical proteinBLASTP
104347310452001728conjugal transfer protein traGQuickGO ontologyBLASTP
10452011045758558hypothetical proteinBLASTP
10457591046049291hypothetical proteinBLASTP
10460461046501456hypothetical proteinBLASTP
10465511047438888VirB11QuickGO ontologyBLASTP
10474381047737300hypothetical proteinBLASTP
10477341047997264hypothetical proteinBLASTP
10479901048283294hypothetical proteinBLASTP
104835310496181266VirB10 type IV secretion proteinQuickGO ontologyBLASTP
104961810511351518conjugal plasmid transfer system proteinQuickGO ontologyBLASTP
10511351052127993hypothetical proteinBLASTP
10521291052257129hypothetical proteinBLASTP
105418410566822499DNA transfer proteinQuickGO ontologyBLASTP
10566951056955261hypothetical proteinBLASTP
10569561057258303hypothetical proteinBLASTP
10572481057517270hypothetical proteinBLASTP
105749510591651671hypothetical proteinBLASTP
1064029106412496hypothetical protein
106461010663521743hypothetical proteinBLASTP
106639310676461254hypothetical proteinBLASTP
10696561070549894hypothetical protein
107065710725041848arginine decarboxylaseQuickGO ontologyBLASTP
107251910736881170type 1 capsular polysaccharide biosynthesis protein JQuickGO ontologyBLASTP