Pre_GI Gene

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Host: NC_017378 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017378:502806 Helicobacter pylori Puno120 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
5028065042511446cag pathogenicity island protein cag delta cag3QuickGO ontologyBLASTP
504261504770510cag pathogenicity island protein cag4QuickGO ontologyBLASTP
507143508135993cag pathogenicity island protein cag alphaQuickGO ontologyBLASTP
508140508739600cag pathogenicity island protein cagZ cag6QuickGO ontologyBLASTP
508752508886135hypothetical proteinBLASTP
5088765145515676cag pathogenicity island protein cag7QuickGO ontologyBLASTP
5145665161341569cag pathogenicity island protein cagX cag8QuickGO ontologyBLASTP
5161875177941608cag pathogenicity island protein WQuickGO ontologyBLASTP
517799518557759cag pathogenicity island protein cagV cag10QuickGO ontologyBLASTP
518831519478648cag pathogenicity island protein cagU cag11QuickGO ontologyBLASTP
519494520336843CAG pathogenicity island protein TQuickGO ontologyBLASTP
520538521137600CAG pathogenicity island protein SQuickGO ontologyBLASTP
521471521683213hypothetical proteinBLASTP
521742521936195hypothetical proteinBLASTP
521948522253306cag pathogenicity island protein cagQ cag14QuickGO ontologyBLASTP
522310522513204hypothetical proteinBLASTP
5240945252241131cag pathogenicity island protein MQuickGO ontologyBLASTP