Pre_GI Gene

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Host: NC_017378 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017378:1489818 Helicobacter pylori Puno120 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
14894811489834354dihydroneopterin aldolaseQuickGO ontologyBLASTP
14898181490144327FrpB-like proteinQuickGO ontologyBLASTP
149029814928892592iron-regulated outer membrane proteinQuickGO ontologyBLASTP
149311714942771161selenocysteine synthaseQuickGO ontologyBLASTP
149435914955461188transcription elongation factor NusAQuickGO ontologyBLASTP
1495679149577496hypothetical protein
14958051496533729hypothetical proteinBLASTP
14965231496960438phage-associated proteinQuickGO ontologyBLASTP
149718514988041620hypothetical proteinBLASTP
14988211499345525hypothetical proteinBLASTP
149934615029123567type II S restriction-modification proteinQuickGO ontologyBLASTP
150301815059362919type III restriction enzymeQuickGO ontologyBLASTP
15059391506520582type III DNA modification enzyme methyltransferaseQuickGO ontologyBLASTP
150784415097151872ATP-dependent DNA helicase RecGQuickGO ontologyBLASTP
15097971510150354hypothetical proteinBLASTP
15101541510789636hypothetical proteinBLASTP
15107861511538753exodeoxyribonuclease IIIQuickGO ontologyBLASTP
1511639151171476tRNA-PheQuickGO ontologyBLASTP
151171715131561440periplasmic competence proteinQuickGO ontologyBLASTP