Pre_GI Gene

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Host: NC_017378 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017378:1175639 Helicobacter pylori Puno120 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
11756391176340702purine-nucleoside phosphorylaseQuickGO ontologyBLASTP
117633711775781242phosphopentomutaseQuickGO ontologyBLASTP
117759011788461257pyrimidine nucleoside transport protein nupCQuickGO ontologyBLASTP
117917111805021332multidrug-efflux transporterQuickGO ontologyBLASTP
11805201181281762hypothetical proteinBLASTP
118129111824421152NaH antiporterQuickGO ontologyBLASTP
118246811838471380hypothetical proteinBLASTP
118400611851811176putative arabinose transporterQuickGO ontologyBLASTP
11854571186200744alpha-carbonic anhydraseQuickGO ontologyBLASTP
118648911882311743hypothetical proteinBLASTP
118829711900691773hypothetical proteinBLASTP
119013511919401806hypothetical proteinBLASTP
119212511931651041aspartate-semialdehyde dehydrogenaseQuickGO ontologyBLASTP
119315211944801329histidyl-tRNA synthetaseQuickGO ontologyBLASTP
119454211955911050ADP-heptose--LPS heptosyltransferase IIQuickGO ontologyBLASTP
11957821196216435hypothetical proteinBLASTP
11965951196723129hypothetical protein
119676111988392079elongation factor GQuickGO ontologyBLASTP