Pre_GI Gene

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Host: NC_017376 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017376:57500 Helicobacter pylori SNT49 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
5878358890108hypothetical proteinBLASTP
5891259298387hypothetical proteinBLASTP
5931459574261hypothetical proteinBLASTP
59656609871332hypothetical proteinBLASTP
6105661271216hypothetical proteinBLASTP
6222162580360integrase-recombinase proteinQuickGO ontologyBLASTP
62643638481206hypothetical proteinBLASTP
63848652331386hypothetical proteinBLASTP
67475688691395hypothetical proteinBLASTP
68870699071038hypothetical proteinBLASTP
70062784888427DNA methylaseQuickGO ontologyBLASTP
7875579411657putative chromosome partitioning proteinQuickGO ontologyBLASTP
7949379777285hypothetical proteinBLASTP
79809809961188hypothetical proteinBLASTP
81021829311911relaxaseQuickGO ontologyBLASTP
8322783541315hypothetical proteinBLASTP
8353483815282hypothetical proteinBLASTP
84137858641728conjugal transfer protein traGQuickGO ontologyBLASTP
8586586422558hypothetical proteinBLASTP
8642386713291hypothetical proteinBLASTP
8671087165456hypothetical proteinBLASTP
8716288103942VirB11 type IV secretion ATPaseQuickGO ontologyBLASTP
8809388398306hypothetical proteinBLASTP
8839588658264hypothetical proteinBLASTP
8865188944294hypothetical proteinBLASTP
89014902491236competence proteinQuickGO ontologyBLASTP
90246917871542conjugal plasmid transfer system proteinQuickGO ontologyBLASTP
9178792773987hypothetical proteinBLASTP
9277592903129hypothetical proteinBLASTP
94832973302499DNA transfer proteinQuickGO ontologyBLASTP