Pre_GI Gene

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Host: NC_017376 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017376:538000 Helicobacter pylori SNT49 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
538913539260348cag pathogenicity island protein cag1QuickGO ontologyBLASTP
539368539730363cag pathogenicity island protein EpsilonQuickGO ontologyBLASTP
5397235411681446cag pathogenicity island protein cag3QuickGO ontologyBLASTP
541178541687510cag pathogenicity island protein GammaQuickGO ontologyBLASTP
5418255440712247CAG pathogenicity island protein 5QuickGO ontologyBLASTP
544080545072993cag pathogenicity island protein alphaQuickGO ontologyBLASTP
545077545676600cag pathogenicity island protein ZQuickGO ontologyBLASTP
5458135512065394cag pathogenicity island protein cag7QuickGO ontologyBLASTP
5512215527861566cag pathogenicity island protein XQuickGO ontologyBLASTP
5528395544461608cag pathogenicity island protein WQuickGO ontologyBLASTP
554451555209759cag island proteinQuickGO ontologyBLASTP
555590556240651cag pathogenicity island protein UQuickGO ontologyBLASTP
556253557095843CAG pathogenicity island protein TQuickGO ontologyBLASTP
557296557895600CAG pathogenicity island protein SQuickGO ontologyBLASTP
558238558441204hypothetical proteinBLASTP
55918155927696hypothetical protein
559451559573123hypothetical proteinBLASTP