Pre_GI Gene

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Host: NC_017376 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017376:1324000 Helicobacter pylori SNT49 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1324483132483335150S ribosomal protein L17QuickGO ontologyBLASTP
132483313258671035DNA-directed RNA polymerase subunit alphaQuickGO ontologyBLASTP
1325879132650562730S ribosomal protein S4QuickGO ontologyBLASTP
1326515132691039630S ribosomal protein S11QuickGO ontologyBLASTP
1326933132729536330S ribosomal protein S13QuickGO ontologyBLASTP
13272991327412114hypothetical protein
13274911327709219translation initiation factor IF-1QuickGO ontologyBLASTP
13277091328470762methionine aminopeptidaseQuickGO ontologyBLASTP
132847013297321263preprotein translocase subunit SecYQuickGO ontologyBLASTP
1329775133017640250S ribosomal protein L15QuickGO ontologyBLASTP
1330196133063944430S ribosomal protein S5QuickGO ontologyBLASTP
1330654133101035750S ribosomal protein L18QuickGO ontologyBLASTP
1331024133156053750S ribosomal protein L6QuickGO ontologyBLASTP
1331571133196639630S ribosomal protein S8QuickGO ontologyBLASTP
1331976133216118630S ribosomal protein S14QuickGO ontologyBLASTP
1332171133271654650S ribosomal protein L5QuickGO ontologyBLASTP
1332729133295022250S ribosomal protein L24QuickGO ontologyBLASTP
1332950133331836950S ribosomal protein L14QuickGO ontologyBLASTP
1333321133358126130S ribosomal protein S17QuickGO ontologyBLASTP
1333595133379520150S ribosomal protein L29QuickGO ontologyBLASTP
1333782133420742650S ribosomal protein L16QuickGO ontologyBLASTP
1334210133491470530S ribosomal protein S3QuickGO ontologyBLASTP
1334918133528636950S ribosomal protein L22QuickGO ontologyBLASTP
1335296133557728230S ribosomal protein S19QuickGO ontologyBLASTP
1335588133641883150S ribosomal protein L2QuickGO ontologyBLASTP
1336434133671528250S ribosomal protein L23QuickGO ontologyBLASTP
1336719133736664850S ribosomal protein L4QuickGO ontologyBLASTP
1337402133797757650S ribosomal protein L3QuickGO ontologyBLASTP
1338014133832831530S ribosomal protein S10QuickGO ontologyBLASTP
133853813396261089hypothetical proteinBLASTP
13398401340418579hypothetical proteinBLASTP
13403921341006615ribonuclease HIIQuickGO ontologyBLASTP
134106313424541392fumarate hydrataseQuickGO ontologyBLASTP
13426281343005378hypothetical proteinBLASTP
134304913442481200hypothetical proteinBLASTP
134424513452521008cation efflux system proteinQuickGO ontologyBLASTP
134525313483663114copper efflux system membrane protein CusAQuickGO ontologyBLASTP
13483631348710348hypothetical proteinBLASTP
13487041349390687branched-chain amino acid transport protein AzlC membrane proteinQuickGO ontologyBLASTP