Pre_GI Gene

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Host: NC_017375 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017375:872478 Helicobacter pylori 83 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
872478873077600CAG pathogenicity island protein 13QuickGO ontologyBLASTP
873279874121843CAG pathogenicity island protein 12QuickGO ontologyBLASTP
874137874784648cag pathogenicity island proteinQuickGO ontologyBLASTP
875058875816759cag pathogenicity island proteinQuickGO ontologyBLASTP
8758218774281608cag pathogenicity island proteinQuickGO ontologyBLASTP
8774818790461566cag pathogenicity island proteinQuickGO ontologyBLASTP
8790618809471887hypothetical proteinBLASTP
8809778844533477DC-EC Repeat superfamily proteinQuickGO ontologyBLASTP
884443884577135hypothetical proteinBLASTP
884590885189600cag pathogenicity island proteinQuickGO ontologyBLASTP
8851798861861008P-type DNA transfer ATPase VirB11QuickGO ontologyBLASTP
8861958884412247cag pathogenicity island proteinQuickGO ontologyBLASTP
888749889258510cag pathogenicity island proteinQuickGO ontologyBLASTP
8892688907131446cag pathogenicity island proteinQuickGO ontologyBLASTP
890729890926198cag pathogenicity island protein cage cag2QuickGO ontologyBLASTP
890942891289348cag pathogenicity island proteinQuickGO ontologyBLASTP
891400892293894Sel1 repeat superfamily proteinQuickGO ontologyBLASTP
892337893329993hypothetical proteinBLASTP
893326894231906GTP-binding protein EraQuickGO ontologyBLASTP
8942318955621332ATP-dependent hsl protease ATP-binding subunit HslUQuickGO ontologyBLASTP
895562896104543ATP-dependent protease HslVUQuickGO ontologyBLASTP
89610889655745050S ribosomal protein L9QuickGO ontologyBLASTP