Pre_GI Gene

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Host: NC_017375 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017375:1317398 Helicobacter pylori 83 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
13167481317410663nicotinamide mononucleotide transporterQuickGO ontologyBLASTP
13173981318012615thiamine diphosphokinaseQuickGO ontologyBLASTP
1318516131886635150S ribosomal protein L17QuickGO ontologyBLASTP
131886613199001035DNA-directed RNA polymerase subunit alphaQuickGO ontologyBLASTP
1319912132053862730S ribosomal protein S4QuickGO ontologyBLASTP
1320548132094339630S ribosomal protein S11QuickGO ontologyBLASTP
1320966132132836330S ribosomal protein S13QuickGO ontologyBLASTP
13215241321742219translation initiation factor IF-1QuickGO ontologyBLASTP
13217421322503762methionine aminopeptidaseQuickGO ontologyBLASTP
132250313237651263preprotein translocase subunit SecYQuickGO ontologyBLASTP
1323803132421040850S ribosomal protein L15QuickGO ontologyBLASTP
1324222132468346230S ribosomal protein S5QuickGO ontologyBLASTP
1324680132503635750S ribosomal protein L18QuickGO ontologyBLASTP
1325050132558653750S ribosomal protein L6QuickGO ontologyBLASTP
1325597132599239630S ribosomal protein S8QuickGO ontologyBLASTP
1326002132618718630S ribosomal protein S14QuickGO ontologyBLASTP
1326197132674254650S ribosomal protein L5QuickGO ontologyBLASTP
1326755132697622250S ribosomal protein L24QuickGO ontologyBLASTP
1326976132734436950S ribosomal protein L14QuickGO ontologyBLASTP
1327347132760726130S ribosomal protein S17QuickGO ontologyBLASTP
1327622132782220150S ribosomal protein L29QuickGO ontologyBLASTP
1327809132823442650S ribosomal protein L16QuickGO ontologyBLASTP
1328237132894170530S ribosomal protein S3QuickGO ontologyBLASTP
1328945132931336950S ribosomal protein L22QuickGO ontologyBLASTP
1329324132960528230S ribosomal protein S19QuickGO ontologyBLASTP
1329617133044783150S ribosomal protein L2QuickGO ontologyBLASTP
1330463133074428250S ribosomal protein L23QuickGO ontologyBLASTP
1330748133139564850S ribosomal protein L4L1 family proteinQuickGO ontologyBLASTP
1331438133201357650S ribosomal protein L3QuickGO ontologyBLASTP
1332050133236431530S ribosomal protein S10QuickGO ontologyBLASTP
133257413336561083ATP-binding proteinQuickGO ontologyBLASTP
13338471334428582hypothetical proteinBLASTP
13344021335016615ribonuclease HIIQuickGO ontologyBLASTP
13350131335735723hypothetical proteinBLASTP
133569013376451956hypothetical proteinBLASTP
133764913390401392fumarate hydrataseQuickGO ontologyBLASTP
13392151339592378hypothetical proteinBLASTP
133959713408351239hypothetical proteinBLASTP
134083213418391008cation efflux system proteinQuickGO ontologyBLASTP