Pre_GI Gene

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Host: NC_017374 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017374:974279 Helicobacter pylori 2017 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
9742799754181140cell division proteinQuickGO ontologyBLASTP
975687975926240hypothetical proteinBLASTP
975950976507558hypothetical proteinBLASTP
976648976983336hypothetical proteinBLASTP
977331978155825Mechanosensitive channel proteinQuickGO ontologyBLASTP
978297978482186hypothetical proteinBLASTP
9805789820051428DNA topoisomerase IQuickGO ontologyBLASTP
982005982508504DNA topoisomerase IQuickGO ontologyBLASTP
983623984369747conjugal plasmid transfer system proteinQuickGO ontologyBLASTP
984363984890528conjugal plasmid transfer system proteinQuickGO ontologyBLASTP
986207986503297hypothetical proteinBLASTP
986493986756264hypothetical proteinBLASTP
986753987052300hypothetical proteinBLASTP
987052987588537Type IV secretion system ATPaseQuickGO ontologyBLASTP
987621987992372Type IV secretion system ATPaseQuickGO ontologyBLASTP
987989988444456hypothetical proteinBLASTP
988441988731291hypothetical proteinBLASTP
988732989289558hypothetical proteinBLASTP
9892909910321743putative conjugal transfer proteinQuickGO ontologyBLASTP
991272991406135hypothetical proteinBLASTP
991547992083537XERCD family proteinintegrase recombinaseQuickGO ontologyBLASTP
992050992637588XERCD family proteinintegrase recombinaseQuickGO ontologyBLASTP
992788992925138hypothetical protein
996463996606144hypothetical proteinBLASTP
996784997146363hypothetical proteinBLASTP