Pre_GI Gene

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Host: NC_017372 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017372:902043 Helicobacter pylori India7 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
902043902879837neuraminyllactose-binding hemagglutininQuickGO ontologyBLASTP
90297890316618950S ribosomal protein L28QuickGO ontologyBLASTP
903209903334126hypothetical protein
9033499044851137putative potassium channel proteinQuickGO ontologyBLASTP
904521904715195hypothetical proteinBLASTP
9049579083343378hypothetical proteinBLASTP
908309908737429hypothetical proteinBLASTP
908910909461552Holliday junction DNA helicase RuvAQuickGO ontologyBLASTP
9094869113301845hypothetical proteinBLASTP
9114239128831461virulence factor MviNQuickGO ontologyBLASTP
9128849142811398cysteinyl-tRNA synthetaseQuickGO ontologyBLASTP
9145049184183915Vacuolating cytotoxin putative signal peptideQuickGO ontologyBLASTP
919712920479768iron compounds ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
920479921459981ABC-type transport system permease IronIII dicitrate transport system permease protein FecD putative membrane proteinQuickGO ontologyBLASTP
921452922306855short-chain oxidoreductaseQuickGO ontologyBLASTP