Pre_GI Gene

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Host: NC_017372 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017372:855384 Helicobacter pylori India7 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
855384855983600CAG pathogenicity island protein 13QuickGO ontologyBLASTP
856185857027843CAG pathogenicity island protein 12QuickGO ontologyBLASTP
857040857690651cag pathogenicity island protein cagU cag11QuickGO ontologyBLASTP
858071858829759cag pathogenicity island protein VQuickGO ontologyBLASTP
8588348604411608cag pathogenicity island protein WQuickGO ontologyBLASTP
8620738673525280cag pathogenicity island protein cag7QuickGO ontologyBLASTP
867342867476135hypothetical proteinBLASTP
867489868088600cag pathogenicity island protein ZQuickGO ontologyBLASTP
868093869085993cag pathogenicity island protein cag alphaQuickGO ontologyBLASTP
8690948713402247cag pathogenicity island protein BetaQuickGO ontologyBLASTP
871478871855378cag pathogenicity island protein gammaQuickGO ontologyBLASTP
8720008734391440cag pathogenicity island protein 3QuickGO ontologyBLASTP
873432873833402cag pathogenicity island protein EpsilonQuickGO ontologyBLASTP
873902874249348cag pathogenicity island protein cag1QuickGO ontologyBLASTP
874421875275855hypothetical proteinBLASTP
875349876341993hypothetical proteinBLASTP
876338877243906GTP-binding protein EraQuickGO ontologyBLASTP
8772438785741332ATP-dependent protease ATP-binding subunit HslUQuickGO ontologyBLASTP
878574879116543ATP-dependent protease peptidase subunitQuickGO ontologyBLASTP
87912087956945050S ribosomal protein L9QuickGO ontologyBLASTP