Pre_GI Gene

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Host: NC_017372 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017372:1373766 Helicobacter pylori India7 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
13731161373778663nicotinamide mononucleotide transporterQuickGO ontologyBLASTP
13737661374380615thiamine pyrophosphokinaseQuickGO ontologyBLASTP
1374706137480196hypothetical protein
1374833137518335150S ribosomal protein L17QuickGO ontologyBLASTP
137518313762171035DNA-directed RNA polymerase subunit alphaQuickGO ontologyBLASTP
1376229137685562730S ribosomal protein S4QuickGO ontologyBLASTP
1376865137726039630S ribosomal protein S11QuickGO ontologyBLASTP
1377284137764636330S ribosomal protein S13QuickGO ontologyBLASTP
13776501377763114hypothetical protein
13778421378060219translation initiation factor IF-1QuickGO ontologyBLASTP
13780601378821762methionine aminopeptidaseQuickGO ontologyBLASTP
137882113800831263preprotein translocase subunit SecYQuickGO ontologyBLASTP
1380126138052740250S ribosomal protein L15QuickGO ontologyBLASTP
1380545138100646230S ribosomal protein S5QuickGO ontologyBLASTP
1381003138135935750S ribosomal protein L18QuickGO ontologyBLASTP
1381373138190953750S ribosomal protein L6QuickGO ontologyBLASTP
1381920138231539630S ribosomal protein S8QuickGO ontologyBLASTP
1382325138251018630S ribosomal protein S14QuickGO ontologyBLASTP
1382520138306554650S ribosomal protein L5QuickGO ontologyBLASTP
1383078138329922250S ribosomal protein L24QuickGO ontologyBLASTP
1383299138366736950S ribosomal protein L14QuickGO ontologyBLASTP
1383670138393026130S ribosomal protein S17QuickGO ontologyBLASTP
1383944138414420150S ribosomal protein L29QuickGO ontologyBLASTP
1384131138455642650S ribosomal protein L16QuickGO ontologyBLASTP
1384559138526370530S ribosomal protein S3QuickGO ontologyBLASTP
1385267138563536950S ribosomal protein L22QuickGO ontologyBLASTP
1385645138592628230S ribosomal protein S19QuickGO ontologyBLASTP
1385937138676783150S ribosomal protein L2QuickGO ontologyBLASTP
1386783138706428250S ribosomal protein L23QuickGO ontologyBLASTP
1387068138771564850S ribosomal protein L4QuickGO ontologyBLASTP
1387750138832557650S ribosomal protein L3QuickGO ontologyBLASTP
1388362138867631530S ribosomal protein S10QuickGO ontologyBLASTP
138884113899741134ATP-binding proteinQuickGO ontologyBLASTP
13901911390769579hypothetical proteinBLASTP
13907431391357615ribonuclease HIIQuickGO ontologyBLASTP
139141313928041392fumarate hydrataseQuickGO ontologyBLASTP
13929791393353375hypothetical proteinBLASTP
139335813945961239hypothetical proteinBLASTP
139459313956181026cation efflux system proteinQuickGO ontologyBLASTP
139561913987263108cation efflux system protein czcAQuickGO ontologyBLASTP