Pre_GI Gene

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Host: NC_017372 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017372:1212000 Helicobacter pylori India7 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
12125041212887384hypothetical protein
12131461213448303hypothetical protein
121346812144609933-oxoacyl-ACP synthaseQuickGO ontologyBLASTP
121448512155041020putative glycerol-3-phosphate acyltransferase PlsXQuickGO ontologyBLASTP
1215572121571814750S ribosomal protein L32QuickGO ontologyBLASTP
12157341216090357hypothetical proteinBLASTP
12161151216528414nucleoside diphosphate kinaseQuickGO ontologyBLASTP
121659412177511158S-adenosylmethionine synthetaseQuickGO ontologyBLASTP
12177511217873123hypothetical protein
12180501218373324putative Hac prophage II proteinQuickGO ontologyBLASTP
12183701218492123hypothetical protein
121848912196371149bacteriophage-related integraseQuickGO ontologyBLASTP
12196341219846213putative Hac prophage II proteinQuickGO ontologyBLASTP
12198481220156309putative Hac prophage II proteinQuickGO ontologyBLASTP
12201531221109957hypothetical proteinBLASTP
12213041221570267hypothetical proteinBLASTP
122158012227461167hypothetical proteinBLASTP
12227431223534792DNA primase DNA GQuickGO ontologyBLASTP
12236091224322714DNA primase DNA GQuickGO ontologyBLASTP
122433512260621728hypothetical proteinBLASTP
122612612319815856hypothetical proteinBLASTP
12319411232135195hypothetical protein
12321351232536402hypothetical proteinBLASTP
12325331233120588hypothetical proteinBLASTP
12333621233910549hypothetical proteinBLASTP
123392212350551134hypothetical proteinBLASTP
12350701235429360hypothetical proteinBLASTP
12354611235886426hypothetical proteinBLASTP
123592512377331809hypothetical proteinBLASTP
12377221237841120hypothetical protein
123784112393971557phage-related CUP0950-like proteinQuickGO ontologyBLASTP
12394621239671210hypothetical protein
12396821239900219hypothetical protein
12399001240223324hypothetical proteinBLASTP
12402251241214990hypothetical proteinBLASTP
12411981241431234hypothetical proteinBLASTP
12414831242028546hypothetical proteinBLASTP
12420311242831801hypothetical proteinBLASTP
12428321243428597hypothetical proteinBLASTP
12434281243754327hypothetical proteinBLASTP
12438081244689882hypothetical proteinBLASTP
12447051245532828hypothetical proteinBLASTP
12455321246359828hypothetical proteinBLASTP