Pre_GI Gene

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Host: NC_017371 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017371:530673 Helicobacter pylori Gambia94/24 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
530021530680660cag island proteinQuickGO ontologyBLASTP
5306735321181446cag island proteinQuickGO ontologyBLASTP
532128532637510cag pathogenicity island protein cag4QuickGO ontologyBLASTP
532950533051102hypothetical proteinBLASTP
5331165353622247CAG pathogenicity island protein 5QuickGO ontologyBLASTP
535371536363993cag island protein DNA transfer proteinQuickGO ontologyBLASTP
536368536967600cag pathogenicity island protein cag6QuickGO ontologyBLASTP
5371025429185817cag pathogenicity island protein Y VirB10-like proteinQuickGO ontologyBLASTP
5429335444981566cag pathogenicity island protein XQuickGO ontologyBLASTP
5445515461581608cag pathogenicity island protein WQuickGO ontologyBLASTP
546163546921759cag pathogenicity island protein VQuickGO ontologyBLASTP
547301547957657cag island proteinQuickGO ontologyBLASTP
547993548835843CAG pathogenicity island protein TQuickGO ontologyBLASTP
549037549630594CAG pathogenicity island protein SQuickGO ontologyBLASTP
549803549922120hypothetical proteinBLASTP
5518285529581131cag island proteinQuickGO ontologyBLASTP