Pre_GI Gene

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Host: NC_017371 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017371:1601452 Helicobacter pylori Gambia94/24 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
160145216040912640iron-regulated outer membrane proteinQuickGO ontologyBLASTP
160431816054781161selenocysteine synthaseQuickGO ontologyBLASTP
160557416067611188transcription elongation factor NusAQuickGO ontologyBLASTP
16080691608203135hypothetical protein
1608231160832999hypothetical protein
1608532160862493hypothetical protein
161478016176892910type III restriction enzymeQuickGO ontologyBLASTP
16176921618279588type III R-M system modification enzymeQuickGO ontologyBLASTP
161827616196581383putative type III restriction enzyme M protein type III adenine specific DNA methyltransferase ModQuickGO ontologyBLASTP
161971016215811872ATP-dependent DNA helicase RecGQuickGO ontologyBLASTP
16216581621996339hypothetical proteinBLASTP
16220001622635636hypothetical proteinBLASTP
16226321623384753exodeoxyribonuclease IIIQuickGO ontologyBLASTP
1623486162356176tRNA-PheQuickGO ontologyBLASTP
162356416250031440hypothetical proteinBLASTP