Pre_GI Gene

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Host: NC_017371 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017371:1358000 Helicobacter pylori Gambia94/24 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1358401135875135150S ribosomal protein L17QuickGO ontologyBLASTP
135875113597851035DNA-directed RNA polymerase subunit alphaQuickGO ontologyBLASTP
1359797136042362730S ribosomal protein S4QuickGO ontologyBLASTP
1360433136082839630S ribosomal protein S11QuickGO ontologyBLASTP
1360851136121336330S ribosomal protein S13QuickGO ontologyBLASTP
13612171361330114hypothetical protein
13614081361626219translation initiation factor IF-1QuickGO ontologyBLASTP
13616261362387762methionine aminopeptidaseQuickGO ontologyBLASTP
136238713636491263preprotein translocase subunit SecYQuickGO ontologyBLASTP
1363689136409040250S ribosomal protein L15QuickGO ontologyBLASTP
1364108136456946230S ribosomal protein S5QuickGO ontologyBLASTP
1364566136492235750S ribosomal protein L18QuickGO ontologyBLASTP
1364936136547253750S ribosomal protein L6QuickGO ontologyBLASTP
1365483136587839630S ribosomal protein S8QuickGO ontologyBLASTP
1365888136607318630S ribosomal protein S14QuickGO ontologyBLASTP
1366083136662854650S ribosomal protein L5QuickGO ontologyBLASTP
1366642136686322250S ribosomal protein L24QuickGO ontologyBLASTP
1366863136723136950S ribosomal protein L14QuickGO ontologyBLASTP
1367234136749426130S ribosomal protein S17QuickGO ontologyBLASTP
1367508136770820150S ribosomal protein L29QuickGO ontologyBLASTP
1367695136812042650S ribosomal protein L16QuickGO ontologyBLASTP
1368123136882770530S ribosomal protein S3QuickGO ontologyBLASTP
1368831136919936950S ribosomal protein L22QuickGO ontologyBLASTP
1369209136949028230S ribosomal protein S19QuickGO ontologyBLASTP
1369502137033283150S ribosomal protein L2QuickGO ontologyBLASTP
1370348137062928250S ribosomal protein L23QuickGO ontologyBLASTP
1370633137128064850S ribosomal protein L4QuickGO ontologyBLASTP
1371315137189057650S ribosomal protein L3QuickGO ontologyBLASTP
1371927137224131530S ribosomal protein S10QuickGO ontologyBLASTP
137245213735401089ATP-binding proteinQuickGO ontologyBLASTP
13737641374345582hypothetical proteinBLASTP
13743311374936606ribonuclease HIIQuickGO ontologyBLASTP
13749661375217252hypothetical proteinBLASTP
137523913766301392fumarate hydrataseQuickGO ontologyBLASTP
13768041377181378hypothetical proteinBLASTP
137718613784241239hypothetical proteinBLASTP
137842113794371017putative cobalt-zinc-cadmium resistance protein CzcB putative signal peptideQuickGO ontologyBLASTP
137943813825453108putative heavy metal efflux pump CzcAQuickGO ontologyBLASTP
13825261382882357hypothetical proteinBLASTP
13828761383562687hypothetical proteinBLASTP