Pre_GI Gene

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Host: NC_017368 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017368:1300000 Helicobacter pylori F16, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1300246130059635150S ribosomal protein L17QuickGO ontologyBLASTP
130059613016301035DNA-directed RNA polymerase subunit alphaQuickGO ontologyBLASTP
1301642130226862730S ribosomal protein S4QuickGO ontologyBLASTP
1302278130267339630S ribosomal protein S11QuickGO ontologyBLASTP
1302696130305836330S ribosomal protein S13QuickGO ontologyBLASTP
13030621303175114hypothetical protein
13032541303472219translation initiation factor IF-1QuickGO ontologyBLASTP
13034721304233762methionine aminopeptidaseQuickGO ontologyBLASTP
130423313054951263preprotein translocase subunit SecYQuickGO ontologyBLASTP
1305533130593440250S ribosomal protein L15QuickGO ontologyBLASTP
1305952130641346230S ribosomal protein S5QuickGO ontologyBLASTP
1306410130676635750S ribosomal protein L18QuickGO ontologyBLASTP
1306780130731653750S ribosomal protein L6QuickGO ontologyBLASTP
1307327130772239630S ribosomal protein S8QuickGO ontologyBLASTP
1307732130791718630S ribosomal protein S14QuickGO ontologyBLASTP
1307927130847254650S ribosomal protein L5QuickGO ontologyBLASTP
1308485130870622250S ribosomal protein L24QuickGO ontologyBLASTP
1308706130907436950S ribosomal protein L14QuickGO ontologyBLASTP
1309077130933726130S ribosomal protein S17QuickGO ontologyBLASTP
1309353130955320150S ribosomal protein L29QuickGO ontologyBLASTP
1309540130996542650S ribosomal protein L16QuickGO ontologyBLASTP
1309968131067270530S ribosomal protein S3QuickGO ontologyBLASTP
1310676131104436950S ribosomal protein L22QuickGO ontologyBLASTP
1311054131133528230S ribosomal protein S19QuickGO ontologyBLASTP
1311347131217783150S ribosomal protein L2QuickGO ontologyBLASTP
1312193131247428250S ribosomal protein L23QuickGO ontologyBLASTP
1312478131312564850S ribosomal protein L4QuickGO ontologyBLASTP
1313160131373557650S ribosomal protein L3QuickGO ontologyBLASTP
1313772131408631530S ribosomal protein S10QuickGO ontologyBLASTP
131425113153781128ATP-binding proteinQuickGO ontologyBLASTP
13156401316221582hypothetical proteinBLASTP
13161951316809615ribonuclease HIIQuickGO ontologyBLASTP
13168401317091252hypothetical proteinBLASTP
131711313185041392fumarate hydrataseQuickGO ontologyBLASTP
13186791319056378hypothetical proteinBLASTP
131907313202991227outer membrane protein HefGQuickGO ontologyBLASTP
13202961321294999cation efflux system proteinQuickGO ontologyBLASTP
132129513244083114cation efflux system proteinQuickGO ontologyBLASTP
13244051324752348hypothetical proteinBLASTP
13247461325432687branched-chain amino acid transport proteinQuickGO ontologyBLASTP