Pre_GI Gene

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Host: NC_017367 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017367:1505780 Helicobacter pylori F57, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
150578015083712592putative IRON-regulated outer membrane proteinQuickGO ontologyBLASTP
150859915097591161selenocysteine synthaseQuickGO ontologyBLASTP
150984715110341188transcription elongation factor NusAQuickGO ontologyBLASTP
151133815124531116Type IIG restriction-modification enzymeQuickGO ontologyBLASTP
151242515151572733Type IIG restriction-modification enzymeQuickGO ontologyBLASTP
151528315174362154hypothetical proteinBLASTP
151749915204142916Type III restriction enzymeQuickGO ontologyBLASTP
15204171521031615Type III DNA modification enzymeQuickGO ontologyBLASTP
152100915223251317Type III DNA modification enzymeQuickGO ontologyBLASTP
152236915242341866DNA recombinaseQuickGO ontologyBLASTP
15243161524669354hypothetical proteinBLASTP
15246731525308636hypothetical proteinBLASTP
15253051526057753exodeoxyribonucleaseQuickGO ontologyBLASTP
1526157152623276tRNA-PheQuickGO ontologyBLASTP
152623515276741440periplasmic competence proteinQuickGO ontologyBLASTP
152789615292631368chromosomal replication initiation proteinQuickGO ontologyBLASTP
15294151529957543purine nucleoside phosphorylaseQuickGO ontologyBLASTP
15299931530232240hypothetical proteinBLASTP