Pre_GI Gene

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Host: NC_017367 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017367:1333811 Helicobacter pylori F57, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
13331611333823663nicotinamide mononucleotide transporterQuickGO ontologyBLASTP
13338111334425615hypothetical proteinBLASTP
1334925133527535150S ribosomal protein L17QuickGO ontologyBLASTP
133527513363091035DNA-directed RNA polymerase subunit alphaQuickGO ontologyBLASTP
1336321133694762730S ribosomal protein S4QuickGO ontologyBLASTP
1336957133735239630S ribosomal protein S11QuickGO ontologyBLASTP
1337375133773736330S ribosomal protein S13QuickGO ontologyBLASTP
13377411337854114hypothetical protein
13379331338151219translation initiation factor IF-1QuickGO ontologyBLASTP
13381511338912762methionine aminopeptidaseQuickGO ontologyBLASTP
133891213401741263preprotein translocase subunit SecYQuickGO ontologyBLASTP
1340212134061340250S ribosomal protein L15QuickGO ontologyBLASTP
1340631134109246230S ribosomal protein S5QuickGO ontologyBLASTP
1341089134144535750S ribosomal protein L18QuickGO ontologyBLASTP
1341459134199553750S ribosomal protein L6QuickGO ontologyBLASTP
1342006134240139630S ribosomal protein S8QuickGO ontologyBLASTP
1342411134259618630S ribosomal protein S14QuickGO ontologyBLASTP
1342606134315154650S ribosomal protein L5QuickGO ontologyBLASTP
1343164134338522250S ribosomal protein L24QuickGO ontologyBLASTP
1343385134375336950S ribosomal protein L14QuickGO ontologyBLASTP
1343756134401626130S ribosomal protein S17QuickGO ontologyBLASTP
1344031134423120150S ribosomal protein L29QuickGO ontologyBLASTP
1344218134464342650S ribosomal protein L16QuickGO ontologyBLASTP
1344646134535070530S ribosomal protein S3QuickGO ontologyBLASTP
1345354134572236950S ribosomal protein L22QuickGO ontologyBLASTP
1345732134601328230S ribosomal protein S19QuickGO ontologyBLASTP
1346025134685583150S ribosomal protein L2QuickGO ontologyBLASTP
1346871134715228250S ribosomal protein L23QuickGO ontologyBLASTP
1347156134780364850S ribosomal protein L4QuickGO ontologyBLASTP
1347838134841357650S ribosomal protein L3QuickGO ontologyBLASTP
1348450134876431530S ribosomal protein S10QuickGO ontologyBLASTP
134892913500561128ATP-binding proteinQuickGO ontologyBLASTP
13503011350879579hypothetical proteinBLASTP
13508531351467615ribonuclease HIIQuickGO ontologyBLASTP
13514981351749252hypothetical proteinBLASTP
135177113531621392fumarate hydrataseQuickGO ontologyBLASTP
13533381353715378hypothetical proteinBLASTP
135372013549581239outer membrane protein HefGQuickGO ontologyBLASTP
135495513559621008cation efflux system proteinQuickGO ontologyBLASTP
135596313590763114cation efflux system proteinQuickGO ontologyBLASTP
13590731359420348hypothetical proteinBLASTP
13594141360100687branched-chain amino acid transport proteinQuickGO ontologyBLASTP