Pre_GI Gene

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Host: NC_017365 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017365:1466500 Helicobacter pylori F30, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
146651514676751161selenocysteine synthaseQuickGO ontologyBLASTP
146776314689501188transcription elongation factor NusAQuickGO ontologyBLASTP
14691471469926780hypothetical proteinBLASTP
14699161470353438hypothetical proteinBLASTP
14705791470899321hypothetical proteinBLASTP
14709811471277297hypothetical proteinBLASTP
14712851472205921hypothetical proteinBLASTP
147260714761913585Type IIG restriction-modification enzymeQuickGO ontologyBLASTP
147631714784552139hypothetical proteinBLASTP
147851814814332916Type III restriction enzymeQuickGO ontologyBLASTP
14814361482017582Type III DNA modification enzymeQuickGO ontologyBLASTP
148201414833961383Type III DNA modification enzymeQuickGO ontologyBLASTP
148343914853041866DNA recombinaseQuickGO ontologyBLASTP
14853861485739354hypothetical proteinBLASTP
14857431486378636hypothetical proteinBLASTP
14863751487127753exodeoxyribonucleaseQuickGO ontologyBLASTP
1487227148730276tRNA-PheQuickGO ontologyBLASTP
148730514887441440periplasmic competence proteinQuickGO ontologyBLASTP