Pre_GI Gene

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Host: NC_017362 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017362:506950 Helicobacter pylori Lithuania75 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
506950507195246hypothetical proteinBLASTP
5071955086401446cag pathogenicity island protein 3QuickGO ontologyBLASTP
508650509159510cag pathogenicity island protein gammaQuickGO ontologyBLASTP
5092785115242247cag pathogenicity island protein 5QuickGO ontologyBLASTP
511533512525993cag pathogenicity island protein alphaQuickGO ontologyBLASTP
512530513129600cag pathogenicity island protein ZQuickGO ontologyBLASTP
5132665190315766cag pathogenicity island protein cag7 cagYQuickGO ontologyBLASTP
5190465206141569cag pathogenicity island protein X VirB9-like proteinQuickGO ontologyBLASTP
5206675222741608cag pathogenicity island protein WQuickGO ontologyBLASTP
522279523037759cag pathogenicity island protein VQuickGO ontologyBLASTP
523434524084651cag pathogenicity island protein UQuickGO ontologyBLASTP
524097524939843CAG pathogenicity island protein 12QuickGO ontologyBLASTP
525136525735600CAG pathogenicity island protein 13QuickGO ontologyBLASTP
5277535288831131cag pathogenicity island protein MQuickGO ontologyBLASTP
528898529818921cag pathogenicity island protein cag17QuickGO ontologyBLASTP