Pre_GI Gene

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Host: NC_017361 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017361:1303553 Helicobacter pylori SouthAfrica7 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
13035531304362810hypothetical proteinBLASTP
13046461304822177hypothetical protein
1304962130531235150S ribosomal protein L17QuickGO ontologyBLASTP
130531213063461035DNA-directed RNA polymerase subunit alphaQuickGO ontologyBLASTP
1306358130698462730S ribosomal protein S4QuickGO ontologyBLASTP
1306994130738939630S ribosomal protein S11QuickGO ontologyBLASTP
1307412130777436330S ribosomal protein S13QuickGO ontologyBLASTP
13077781307891114hypothetical protein
13079701308188219translation initiation factor IF-1QuickGO ontologyBLASTP
13081881308949762methionine aminopeptidaseQuickGO ontologyBLASTP
130894913102111263preprotein translocase subunit SecYQuickGO ontologyBLASTP
1310254131065540250S ribosomal protein L15QuickGO ontologyBLASTP
1310673131111644430S ribosomal protein S5QuickGO ontologyBLASTP
1311131131148735750S ribosomal protein L18QuickGO ontologyBLASTP
1311501131203753750S ribosomal protein L6QuickGO ontologyBLASTP
1312048131244339630S ribosomal protein S8QuickGO ontologyBLASTP
1312453131263818630S ribosomal protein S14QuickGO ontologyBLASTP
1312648131319354650S ribosomal protein L5QuickGO ontologyBLASTP
1313205131342622250S ribosomal protein L24QuickGO ontologyBLASTP
1313426131379436950S ribosomal protein L14QuickGO ontologyBLASTP
1313797131405726130S ribosomal protein S17QuickGO ontologyBLASTP
1314071131427120150S ribosomal protein L29QuickGO ontologyBLASTP
1314258131468342650S ribosomal protein L16QuickGO ontologyBLASTP
1314686131539070530S ribosomal protein S3QuickGO ontologyBLASTP
1315394131576236950S ribosomal protein L22QuickGO ontologyBLASTP
1315772131605328230S ribosomal protein S19QuickGO ontologyBLASTP
1316065131689583150S ribosomal protein L2QuickGO ontologyBLASTP
1316911131719228250S ribosomal protein L23QuickGO ontologyBLASTP
1317196131784364850S ribosomal protein L4QuickGO ontologyBLASTP
1317877131845257650S ribosomal protein L3QuickGO ontologyBLASTP
1318486131880031530S ribosomal protein S10QuickGO ontologyBLASTP
131900913200971089hypothetical proteinBLASTP
13203121320890579hypothetical proteinBLASTP
13208641321478615ribonuclease HIIQuickGO ontologyBLASTP
13215091321700192hypothetical proteinBLASTP
132178413231751392fumarate hydrataseQuickGO ontologyBLASTP
13233621323739378hypothetical proteinBLASTP
132375013249851236hypothetical proteinBLASTP
13249821325977996cation efflux system proteinQuickGO ontologyBLASTP
132598013290783099cation efflux system proteinQuickGO ontologyBLASTP