Pre_GI Gene

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Host: NC_017359 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017359:813500 Helicobacter pylori Sat464 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
813679814278600CAG pathogenicity island protein 13QuickGO ontologyBLASTP
814480815322843CAG pathogenicity island protein 12QuickGO ontologyBLASTP
815338815985648cag pathogenicity island protein cagU cag11QuickGO ontologyBLASTP
816258817016759cag pathogenicity island protein cagV cag10QuickGO ontologyBLASTP
8170218186281608cag pathogenicity island protein cagW cag9QuickGO ontologyBLASTP
8186818202491569cag pathogenicity island protein cagX cag8QuickGO ontologyBLASTP
8202648254235160cag pathogenicity island protein cagY cag7QuickGO ontologyBLASTP
825413825547135hypothetical proteinBLASTP
825560826159600cag pathogenicity island protein cagZ cag6QuickGO ontologyBLASTP
826164827156993cag pathogenicity island protein cag alphaQuickGO ontologyBLASTP
8271658294112247cag pathogenicity island protein cag beta cag5QuickGO ontologyBLASTP
829530830039510cag pathogenicity island protein cag4QuickGO ontologyBLASTP
8300498315781530cag pathogenicity island protein cag delta cag3QuickGO ontologyBLASTP
831721832068348cag pathogenicity island protein cag zeta cag1QuickGO ontologyBLASTP
832281833111831hypothetical proteinBLASTP
833182834174993hypothetical proteinBLASTP
834171835076906GTP-binding protein EraQuickGO ontologyBLASTP
8350768364071332ATP-dependent protease ATP-binding subunit HslUQuickGO ontologyBLASTP
836407836949543ATP-dependent protease peptidase subunitQuickGO ontologyBLASTP