Pre_GI Gene

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Host: NC_017358 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017358:182854 Helicobacter pylori Cuz20 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
182854183621768fumarate reductase cytochrome b-556 subunitQuickGO ontologyBLASTP
183834184538705triosephosphate isomeraseQuickGO ontologyBLASTP
184548185375828enoyl-ACP reductaseQuickGO ontologyBLASTP
1853851863951011UDP-3-O-3-hydroxymyristoyl glucosamine N-acyltransferaseQuickGO ontologyBLASTP
186974187795822hypothetical proteinBLASTP
187795188646852hypothetical proteinBLASTP
188663189544882hypothetical proteinBLASTP
189598189885288hypothetical proteinBLASTP
189924190481558hypothetical proteinBLASTP
190481191293813hypothetical proteinBLASTP
191297191842546hypothetical proteinBLASTP
191898192113216hypothetical proteinBLASTP
1921131931171005hypothetical proteinBLASTP
193119193445327hypothetical proteinBLASTP
193442193669228hypothetical proteinBLASTP
193680193892213hypothetical proteinBLASTP
1939511955101560phage-related CUP0950-like proteinQuickGO ontologyBLASTP
195503195613111hypothetical protein
1956161974211806hypothetical proteinBLASTP
197491197919429hypothetical proteinBLASTP
198059198418360hypothetical proteinBLASTP
1984321995531122hypothetical proteinBLASTP
199564200124561hypothetical proteinBLASTP
200369200956588hypothetical proteinBLASTP
200953201339387hypothetical proteinBLASTP
2014592072995841hypothetical proteinBLASTP
2073762090281653hypothetical proteinBLASTP
2090322106031572DNA primase DNA GQuickGO ontologyBLASTP
2106002117751176hypothetical proteinBLASTP
211786212052267hypothetical proteinBLASTP
212244213194951hypothetical proteinBLASTP
213191213499309putative Hac prophage II proteinQuickGO ontologyBLASTP
213502213708207hypothetical proteinBLASTP
2137052148501146bacteriophage-related integraseQuickGO ontologyBLASTP
214847214975129hypothetical proteinBLASTP
214962215261300putative Hac prophage II proteinQuickGO ontologyBLASTP
2155602167171158S-adenosylmethionine synthetaseQuickGO ontologyBLASTP
216784217197414nucleoside diphosphate kinaseQuickGO ontologyBLASTP
217222217578357hypothetical proteinBLASTP
21759421774014750S ribosomal protein L32QuickGO ontologyBLASTP
2178082188271020putative glycerol-3-phosphate acyltransferase PlsXQuickGO ontologyBLASTP