Pre_GI Gene

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Host: NC_017358 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017358:1342000 Helicobacter pylori Cuz20 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1342064134241435150S ribosomal protein L17QuickGO ontologyBLASTP
134241413434481035DNA-directed RNA polymerase subunit alphaQuickGO ontologyBLASTP
1343460134408662730S ribosomal protein S4QuickGO ontologyBLASTP
1344096134449139630S ribosomal protein S11QuickGO ontologyBLASTP
1344514134487636330S ribosomal protein S13QuickGO ontologyBLASTP
13448801344993114hypothetical protein
13450721345290219translation initiation factor IF-1QuickGO ontologyBLASTP
13452901346051762methionine aminopeptidaseQuickGO ontologyBLASTP
134605113473131263preprotein translocase subunit SecYQuickGO ontologyBLASTP
1347351134775240250S ribosomal protein L15QuickGO ontologyBLASTP
1347770134821344430S ribosomal protein S5QuickGO ontologyBLASTP
1348228134858435750S ribosomal protein L18QuickGO ontologyBLASTP
1348598134913453750S ribosomal protein L6QuickGO ontologyBLASTP
1349145134954039630S ribosomal protein S8QuickGO ontologyBLASTP
1349550134973518630S ribosomal protein S14QuickGO ontologyBLASTP
1349745135029054650S ribosomal protein L5QuickGO ontologyBLASTP
1350303135052422250S ribosomal protein L24QuickGO ontologyBLASTP
1350524135089236950S ribosomal protein L14QuickGO ontologyBLASTP
1350895135115526130S ribosomal protein S17QuickGO ontologyBLASTP
1351170135137020150S ribosomal protein L29QuickGO ontologyBLASTP
1351357135178242650S ribosomal protein L16QuickGO ontologyBLASTP
1351785135248970530S ribosomal protein S3QuickGO ontologyBLASTP
1352493135286136950S ribosomal protein L22QuickGO ontologyBLASTP
1352871135315228230S ribosomal protein S19QuickGO ontologyBLASTP
1353164135399483150S ribosomal protein L2QuickGO ontologyBLASTP
1354010135429128250S ribosomal protein L23QuickGO ontologyBLASTP
1354295135494264850S ribosomal protein L4QuickGO ontologyBLASTP
1354977135555257650S ribosomal protein L3QuickGO ontologyBLASTP
1355589135590331530S ribosomal protein S10QuickGO ontologyBLASTP
135611313572011089ATP-binding proteinQuickGO ontologyBLASTP
13574381358019582hypothetical proteinBLASTP
13579931358607615ribonuclease HIIQuickGO ontologyBLASTP
13586511358866216hypothetical proteinBLASTP
135888913602801392fumarate hydrataseQuickGO ontologyBLASTP
13604561360833378hypothetical proteinBLASTP
136083813620761239hypothetical proteinBLASTP
136207313630801008cation efflux system protein czcAQuickGO ontologyBLASTP
136308113662033123cation efflux system protein czcAQuickGO ontologyBLASTP
13661931366540348hypothetical proteinBLASTP
13665341367220687branched-chain amino acid transport proteinQuickGO ontologyBLASTP