Pre_GI Gene

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Host: NC_017357 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017357:973392 Helicobacter pylori 908 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
9733929745311140cell division proteinQuickGO ontologyBLASTP
974800975039240hypothetical proteinBLASTP
975063975620558hypothetical proteinBLASTP
975761976096336hypothetical proteinBLASTP
976444977268825hypothetical proteinBLASTP
977410977604195hypothetical proteinBLASTP
9796919811181428DNA topoisomeraseIQuickGO ontologyBLASTP
981118981621504DNA topoisomeraseIQuickGO ontologyBLASTP
982736983482747hypothetical proteinBLASTP
983476984003528conjugal plasmid transfer system proteinQuickGO ontologyBLASTP
985320985616297hypothetical proteinBLASTP
985606985869264hypothetical proteinBLASTP
985866986165300hypothetical proteinBLASTP
986165986701537typeIIIV secretion system ATP hydrolaseQuickGO ontologyBLASTP
986734987105372type IV secretion ATPaseQuickGO ontologyBLASTP
987102987557456hypothetical proteinBLASTP
987554987844291hypothetical proteinBLASTP
987845988402558hypothetical proteinBLASTP
9884039901451743hypothetical proteinBLASTP
990385990519135hypothetical proteinBLASTP
990660991196537hypothetical proteinBLASTP
991163991750588integraserecombinaseQuickGO ontologyBLASTP
992124992486363hypothetical proteinBLASTP
992613992984372hypothetical proteinBLASTP
992956993906951hypothetical proteinBLASTP
993878994480603hypothetical proteinBLASTP
994662994880219hypothetical proteinBLASTP
994918995067150hypothetical protein
9951419969881848Arginine decarboxylaseQuickGO ontologyBLASTP
9970029981711170type1 capsular polysaccharide biosynthesis protein JQuickGO ontologyBLASTP