Pre_GI Gene

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Host: NC_017355 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017355:493237 Helicobacter pylori v225d chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
493237493584348Cag1QuickGO ontologyBLASTP
4938114952561446cag pathogenicity island proteinQuickGO ontologyBLASTP
495266495775510hypothetical proteinBLASTP
4958944981402247cag pathogenicity island protein cagbQuickGO ontologyBLASTP
498149499141993P-type DNA transfer ATPase VirB11QuickGO ontologyBLASTP
499146499571426cag pathogenicity island protein cagZQuickGO ontologyBLASTP
4998825051885307cag pathogenicity island proteinQuickGO ontologyBLASTP
5052035067711569Cag8QuickGO ontologyBLASTP
5068245084311608Cytochrome bQuickGO ontologyBLASTP
508436509194759cag pathogenicity island protein cagVQuickGO ontologyBLASTP
509446510093648cag pathogenicity island protein cagUQuickGO ontologyBLASTP
510109510951843cag pathogenicity island proteinQuickGO ontologyBLASTP
511153511614462cag pathogenicity island proteinQuickGO ontologyBLASTP
511925512050126hypothetical proteinBLASTP
512139512249111hypothetical protein
512305512472168hypothetical protein
512484512672189aspartylglutamyl-tRNA amidotransferase subunit BQuickGO ontologyBLASTP
512701513006306cag pathogenicity island proteinQuickGO ontologyBLASTP
513063513218156hypothetical proteinBLASTP
513319513420102hypothetical protein
513828514055228cag pathogenicity island protein cagBQuickGO ontologyBLASTP