Pre_GI Gene

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Host: NC_017355 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017355:1299874 Helicobacter pylori v225d chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
12992241299886663nicotinamide mononucleotide transporter PnuCQuickGO ontologyBLASTP
12998741300488615thiamine pyrophosphokinaseQuickGO ontologyBLASTP
13006191300771153hypothetical protein
13007981300902105hypothetical protein
13008761301004129hypothetical proteinBLASTP
1301001130135135150S ribosomal protein L17QuickGO ontologyBLASTP
130135113023851035DNA-directed RNA polymerase subunit alphaQuickGO ontologyBLASTP
1302397130302362730S ribosomal protein S4QuickGO ontologyBLASTP
1303033130342839630S ribosomal protein S11QuickGO ontologyBLASTP
1303451130381336330S ribosomal protein S13QuickGO ontologyBLASTP
1303817130393011450S ribosomal protein L36QuickGO ontology
13040091304227219translation initiation factor IF-1QuickGO ontologyBLASTP
13042271304988762methionine aminopeptidaseQuickGO ontologyBLASTP
130498813062501263preprotein translocase subunit SecYQuickGO ontologyBLASTP
1306288130668940250S ribosomal protein L15QuickGO ontologyBLASTP
1306707130715044430S ribosomal protein S5QuickGO ontologyBLASTP
1307165130752135750S ribosomal protein L18QuickGO ontologyBLASTP
1307535130807153750S ribosomal protein L6QuickGO ontologyBLASTP
1308082130847739630S ribosomal protein S8QuickGO ontologyBLASTP
1308682130922754650S ribosomal protein L5QuickGO ontologyBLASTP
1309240130946122250S ribosomal protein L24QuickGO ontologyBLASTP
1309461130982936950S ribosomal protein L14QuickGO ontologyBLASTP
1309832131009226130S ribosomal protein S17QuickGO ontologyBLASTP
1310106131030620150S ribosomal protein L29QuickGO ontologyBLASTP
1310293131071842650S ribosomal protein L16QuickGO ontologyBLASTP
1310721131142570530S ribosomal protein S3QuickGO ontologyBLASTP
1311429131179736950S ribosomal protein L22QuickGO ontologyBLASTP
1311807131208828230S ribosomal protein S19QuickGO ontologyBLASTP
1312100131293083150S ribosomal protein L2QuickGO ontologyBLASTP
1312946131322728250S ribosomal protein L23QuickGO ontologyBLASTP
1313231131387864850S ribosomal protein L4QuickGO ontologyBLASTP
1313913131448857650S ribosomal protein L3QuickGO ontologyBLASTP
1314525131483931530S ribosomal protein S10QuickGO ontologyBLASTP
131504813161361089hypothetical proteinBLASTP
13164301317011582hypothetical proteinBLASTP
13169851317449465Ribonuclease HIIQuickGO ontologyBLASTP
13176301317881252hypothetical proteinBLASTP
131790313192941392class II fumarate hydrataseQuickGO ontologyBLASTP
13194701319847378hypothetical proteinBLASTP
131985213210901239ParamyosinQuickGO ontologyBLASTP
132108713220941008Cation efflux system protein czcBQuickGO ontologyBLASTP
132209513252083114CzcA family heavy metal efflux pumpQuickGO ontologyBLASTP
13252051325552348hypothetical proteinBLASTP
13255461326232687azaleucine resistance protein AzlCQuickGO ontologyBLASTP