Pre_GI Gene

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Host: NC_017354 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017354:848500 Helicobacter pylori 52 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
848585849184600cag pathogenicity island protein SQuickGO ontologyBLASTP
849386850228843cag pathogenicity island protein TQuickGO ontologyBLASTP
850244850891648cag pathogenicity island protein UQuickGO ontologyBLASTP
851272852030759cag pathogenicity island protein VQuickGO ontologyBLASTP
8520358536421608cag pathogenicity island protein WQuickGO ontologyBLASTP
8536958552631569penicillin-binding proteinQuickGO ontologyBLASTP
8552788609745697conjugation TrbI family proteinQuickGO ontologyBLASTP
861111861710600cag pathogenicity island protein ZQuickGO ontologyBLASTP
861715862707993P-type DNA transfer ATPase VirB11QuickGO ontologyBLASTP
8627168649622247cag pathogenicity island protein 5QuickGO ontologyBLASTP
865080865589510cag pathogenicity island protein 4QuickGO ontologyBLASTP
8655998670441446cag pathogenicity island protein 3QuickGO ontologyBLASTP
867273867716444cag pathogenicity island protein cag1QuickGO ontologyBLASTP
867792868646855hypothetical proteinBLASTP
868720869712993hypothetical proteinBLASTP
869709870614906GTP-binding protein EraQuickGO ontologyBLASTP
8706148719361323ATP-dependent protease ATP-binding subunitQuickGO ontologyBLASTP
871945872487543ATP-dependent protease peptidase subunitQuickGO ontologyBLASTP
87249187294045050S ribosomal protein L9QuickGO ontologyBLASTP