Pre_GI Gene

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Host: NC_017354 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017354:1465925 Helicobacter pylori 52 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
146592514670851161selenocysteine synthaseQuickGO ontologyBLASTP
146717414683611188transcription elongation factor NusAQuickGO ontologyBLASTP
146869014724393750type IIS restriction-modification proteinQuickGO ontologyBLASTP
147254914746992151putative cytoplasmic proteinQuickGO ontologyBLASTP
147476214771072346hypothetical proteinBLASTP
14776801478288609hypothetical proteinBLASTP
147826614797141449adenine specific DNA methylaseQuickGO ontologyBLASTP
147975714816221866ATP-dependent DNA helicase RecGQuickGO ontologyBLASTP
14817041482051348hypothetical proteinBLASTP
14820551482690636hypothetical proteinBLASTP
14826871483439753exodeoxyribonucleaseQuickGO ontologyBLASTP
1483539148361476tRNA-PheQuickGO ontologyBLASTP
148361714850561440periplasmic competence proteinQuickGO ontologyBLASTP
148527714866441368chromosomal replication initiator protein DnaAQuickGO ontologyBLASTP
14867961487332537purine nucleoside phosphorylaseQuickGO ontologyBLASTP
14873791487618240hypothetical proteinBLASTP
148761914894121794D-fructose-6-phosphate amidotransferaseQuickGO ontologyBLASTP