Pre_GI Gene

Some Help

Host: NC_017328 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017328:4417000 Shigella flexneri 2002017 chromosome, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
44171794418081903minor fimbrial subunit D-mannose specific adhesinQuickGO ontologyBLASTP
44186164419146531Minor fimbrial subunit polypeptideQuickGO ontologyBLASTP
44218374422040204putative integrase encoded by prophage CP-933KQuickGO ontologyBLASTP
44226354423360726Type I fimbrial chaperoneQuickGO ontologyBLASTP
44233974424035639FimI fimbrial proteinQuickGO ontologyBLASTP
44240014424549549Type-1 fimbrial major subunitQuickGO ontologyBLASTP
44250304425626597Type 1 fimbriae regulatory protein fimEQuickGO ontologyBLASTP
44262214426706486Recombinase regulator for fimAQuickGO ontologyBLASTP
44281514428876726putative N-acetylneuraminic acid outer membrane channel protein nanC precursorQuickGO ontologyBLASTP
442878844300021215hypothetical proteinBLASTP
44300674431047981hypothetical proteinBLASTP
44315164432019504IS1 orfBQuickGO ontologyBLASTP
44321334432360228IS600 ORF2QuickGO ontologyBLASTP
44323084433003696putative transcriptional regulatorQuickGO ontologyBLASTP
44334734433757285putative transposase ykgNQuickGO ontologyBLASTP
44341644434982819IS600 ORF2QuickGO ontologyBLASTP
44349944435893900ISEhe3 transposase orfBQuickGO ontologyBLASTP
44362134436536324IS600 ORF2QuickGO ontologyBLASTP
44367184437113396IS1 orfBQuickGO ontologyBLASTP
44381154438474360IS911 orfAQuickGO ontologyBLASTP
443844944396601212putative P4-type integraseQuickGO ontologyBLASTP
4439862443994382tRNA-LeuQuickGO ontologyBLASTP
444009744411581062putative Zn-dependent alcohol dehydrogenaseQuickGO ontologyBLASTP
444123944427891551hypothetical proteinBLASTP