Pre_GI Gene

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Host: NC_017328 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017328:385552 Shigella flexneri 2002017 chromosome, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
38555238741418631-deoxy-D-xylulose-5-phosphate synthaseQuickGO ontologyBLASTP
387439388338900geranyltranstransferaseQuickGO ontologyBLASTP
388338388580243exodeoxyribonuclease 7 small subunitQuickGO ontologyBLASTP
3887863902341449Thiamine biosynthesis protein thiIQuickGO ontologyBLASTP
3902883908845974-methyl-5B-hydroxyethyl-thiazole monophosphate biosynthesis ThiJ proteinQuickGO ontologyBLASTP
3908413917529122-dehydropantoate 2-reductaseQuickGO ontologyBLASTP
391920392411492hypothetical proteinBLASTP
3924713942011731hypothetical proteinBLASTP
3942543966772424hypothetical proteinBLASTP
396752397255504putative IS1 family transposaseQuickGO ontologyBLASTP
397303397764462GNAT family acetyltransferaseQuickGO ontologyBLASTP
397836398195360hypothetical proteinBLASTP
398331399221891Cytochrome o ubiquinol oxidase C subunitQuickGO ontologyBLASTP
399233399562330Cytochrome O ubiquinol oxidase protein CyoDQuickGO ontologyBLASTP
399562400176615Cytochrome o ubiquinol oxidase subunit 3QuickGO ontologyBLASTP
402179402646468Ubiquinol oxidase subunit 2QuickGO ontologyBLASTP
402709403515807ISSfl3 orfCDQuickGO ontologyBLASTP
403491403625135ISSfl4 ORF3QuickGO ontologyBLASTP
403645403992348ISSfl4 ORF2QuickGO ontologyBLASTP
403989404663675ISSfl4 ORF1QuickGO ontologyBLASTP
4050334065081476Beta-lactamase induction signal transducer AmpGQuickGO ontologyBLASTP
406552407232681putative polymeraseproteinaseQuickGO ontologyBLASTP
407435407752318Protein bolAQuickGO ontologyBLASTP
407686407949264hypothetical proteinBLASTP
4080964093941299trigger factor TigQuickGO ontologyBLASTP