Pre_GI Gene

Some Help

Host: NC_017328 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017328:3794105 Shigella flexneri 2002017 chromosome, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
37941053794608504IS1 ORF2QuickGO ontologyBLASTP
37947223794865144putative integrase encoded by prophage CP-933KQuickGO ontologyBLASTP
379503237960571026L-threonine 3-dehydrogenaseQuickGO ontologyBLASTP
3796067379726311972-amino-3-ketobutyrate CoA ligaseQuickGO ontologyBLASTP
37975383798410873Involved in lipopolysaccharide biosynthesisQuickGO ontologyBLASTP
37986993799631933ADP-L-glycero-D-manno-heptose-6-epimeraseQuickGO ontologyBLASTP
379964138006871047ADP-heptose--lps heptosyltransferase IIQuickGO ontologyBLASTP
38006913801683993putative ADP-heptoseLPS heptosyltransferaseQuickGO ontologyBLASTP
380168038028881209Lipid A-core surface polymer ligaseQuickGO ontologyBLASTP
380292438040661143Lipopolysaccharide 12-N-acetylglucosaminetransferaseQuickGO ontologyBLASTP
380407538050881014Lipopolysaccharide 12-glucosyltransferaseQuickGO ontologyBLASTP
38051133805508396putative LPS biosynthesis proteinQuickGO ontologyBLASTP
380584638068531008UDP-D-galactoseGlucosyllipopolysaccharide- alpha-1 3-D- galactosyltransferaseQuickGO ontologyBLASTP
38068963807702807Lipopolysaccharide core biosynthesis proteinQuickGO ontologyBLASTP
380768638088101125LPS alpha13-glucosyltransferaseQuickGO ontologyBLASTP
380880738098651059putative ADP-heptoseLPS heptosyltransferaseQuickGO ontologyBLASTP
38102233810726504IS1 orfBQuickGO ontologyBLASTP
38108403811019180putative integrase encoded by prophage CP-933KQuickGO ontologyBLASTP
3811054381233112783-deoxy-D-manno-octulosonic-acid transferaseQuickGO ontologyBLASTP
38123393812818480Phosphopantetheine adenylyltransferaseQuickGO ontologyBLASTP
38128573813666810Formamidopyrimidine-DNA glycosylaseQuickGO ontologyBLASTP
3813764381393116850S ribosomal protein L33QuickGO ontologyBLASTP
3813952381418823750S ribosomal protein L28QuickGO ontologyBLASTP
38144053815079675DNA repair proteinQuickGO ontologyBLASTP
381524538164651221Flavoprotein affecting synthesis of DNA and pantothenate metabolismQuickGO ontologyBLASTP
38164433816901459deoxyuridine 5-triphosphate nucleotidohydrolaseQuickGO ontologyBLASTP
38170083817604597putative transcriptional regulatorQuickGO ontologyBLASTP
38176413818282642orotate phosphoribosyltransferaseQuickGO ontologyBLASTP
38183483819064717Ribonuclease PHQuickGO ontologyBLASTP