Pre_GI Gene

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Host: NC_017328 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017328:3625000 Shigella flexneri 2002017 chromosome, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
362504036261671128ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
362616436288992736ATPaseQuickGO ontologyBLASTP
362889636299631068Auxiliary transport protein membrane fusion protein MFP familyQuickGO ontologyBLASTP
363032936319511623hypothetical proteinBLASTP
363221336339161704hypothetical proteinBLASTP
36353043635780477hypothetical proteinBLASTP
36357733636537765Transcriptional regulator CadCQuickGO ontologyBLASTP
36376513638163513hypothetical proteinBLASTP
363830236394501149putative fimbriae usherQuickGO ontologyBLASTP
36399113640243333putative IS2 ORFQuickGO ontologyBLASTP
364101136420901080putative fimbrial protein remnantQuickGO ontologyBLASTP
36421343642937804Possible chaperoneQuickGO ontologyBLASTP
36433623644096735hypothetical protein
364409636453701275hypothetical proteinBLASTP
36453863645685300ISSd1 transposase orfAB fusionQuickGO ontologyBLASTP
36456963646199504IS1 orfBQuickGO ontologyBLASTP
36463133646516204IS150 ORF1QuickGO ontologyBLASTP
364692236481211200hypothetical proteinBLASTP
364835336498521500Low-affinity phosphate transport proteinQuickGO ontologyBLASTP