Pre_GI Gene

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Host: NC_017328 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017328:303987 Shigella flexneri 2002017 chromosome, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3039873052311245esterase frsAQuickGO ontologyBLASTP
305418305690273Sigma factor-binding protein crlQuickGO ontologyBLASTP
3057293067841056Outer membrane pore protein EQuickGO ontologyBLASTP
307154307657504putative IS1 family transposaseQuickGO ontologyBLASTP
3078483089511104glutamate 5-kinaseQuickGO ontologyBLASTP
3089633102161254gamma-glutamyl phosphate reductaseQuickGO ontologyBLASTP
31033131040373tRNA-ThrQuickGO ontology
3104213115811161phage integrase family site-specific recombinaseQuickGO ontologyBLASTP
311458311805348xisQuickGO ontologyBLASTP
311896312267372hypothetical proteinBLASTP
312341312520180hypothetical protein
312617313291675putative bacteriophage proteinQuickGO ontologyBLASTP
313288313737450hypothetical proteinBLASTP
313857314024168hypothetical proteinBLASTP
314041314355315hypothetical proteinBLASTP
314367314807441hypothetical proteinBLASTP
314833315735903putative phage-related DNA recombination proteinQuickGO ontologyBLASTP
315732316043312hypothetical proteinBLASTP
316021316128108hypothetical proteinBLASTP
316125316400276ral proteinQuickGO ontologyBLASTP
316980317288309antitermination of transcription at nut site proteinQuickGO ontologyBLASTP
317642318337696CI proteinQuickGO ontologyBLASTP
318413318628216cro proteinQuickGO ontologyBLASTP
318738319034297putative regulatory protein CII of bacteriophageQuickGO ontologyBLASTP
319067319228162Gp53QuickGO ontologyBLASTP
319215320105891O proteinQuickGO ontologyBLASTP
3200803215311452Replication protein PQuickGO ontologyBLASTP
32153132162999Gp56QuickGO ontologyBLASTP
321616321828213Gp60QuickGO ontology
321809322249441Protein ninBQuickGO ontologyBLASTP
322246322419174NinD proteinQuickGO ontologyBLASTP
322386322562177NinE proteinQuickGO ontology
322559322729171Gp64QuickGO ontologyBLASTP
322722323444723DNA-binding protein RoiQuickGO ontologyBLASTP
323444323734291Gp66QuickGO ontologyBLASTP
323731324093363Holiday-junction resolvaseQuickGO ontologyBLASTP
324090324278189Gp68QuickGO ontologyBLASTP
324275324793519Q proteinQuickGO ontologyBLASTP
325292325615324S proteinQuickGO ontologyBLASTP
325599326075477R proteinQuickGO ontologyBLASTP
326072326509438Rz proteinQuickGO ontologyBLASTP
326497326649153hypothetical proteinBLASTP