Pre_GI Gene

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Host: NC_017328 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017328:2785309 Shigella flexneri 2002017 chromosome, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
27853092786175867Inner membrane protein ypjDQuickGO ontologyBLASTP
278622027874821263putative CBS domain-containing proteinQuickGO ontologyBLASTP
27875372788130594protein grpEQuickGO ontologyBLASTP
27880952788256162hypothetical proteinBLASTP
27882532789131879putative inorganic polyphosphateATP-NAD kinaseQuickGO ontologyBLASTP
278921727908781662DNA repair protein RecNQuickGO ontologyBLASTP
27910272791368342Small protein AQuickGO ontologyBLASTP
27914302791804375hypothetical proteinBLASTP
27917102792186477hypothetical proteinBLASTP
27923182792800483SsrA-binding proteinQuickGO ontologyBLASTP
279358227948231242putative CP4-57-type integraseQuickGO ontologyBLASTP
27953252795720396IS1 transposaseQuickGO ontologyBLASTP
27958302796138309putative transposaseQuickGO ontologyBLASTP
27961352797001867IS3 ORF2QuickGO ontologyBLASTP
2797252279732473tRNA-MetQuickGO ontologyBLASTP
279788328001352253alpha amylaseQuickGO ontologyBLASTP
280036628014031038hypothetical proteinBLASTP
280135728026911335FAD-dependent oxidoreductaseQuickGO ontologyBLASTP
2804329280545611284-aminobutyrate aminotransferaseQuickGO ontologyBLASTP
280569428070941401Transport permease protein of gamma-aminobutyrateQuickGO ontologyBLASTP
28071152807777663putative transcriptional regulatorQuickGO ontologyBLASTP
28077782808227450phospholipid-binding proteinQuickGO ontologyBLASTP